Back to Search
Start Over
Antibodies to BK virus structural and tumor antigens in human sera from normal persons and from patients with various diseases, including neoplasia
- Source :
- Infection and immunity. 13(6)
- Publication Year :
- 1976
-
Abstract
- Sera from 1,279 patients with various diseases were examined for the presence of antibodies to BK virus (BKV) capsid antigens. The percentage of positive sera was comparable in all the diseases except rheumatoid arthritis and chronic nephropathies, where a slightly higher prevalence was found. Sera from 952 patients with tumors were examined for the presence of antibodies to BKV tumor and capsid antigens in comparison with a matched control group of 501 blood donors. Sera from 11 tumor patients (1.15%) and from 4 normal controls (0.80%) had antibodies to BKV tumor antigen. No higher prevalence of antibodies to BKV capsid antigens was found in any cancer type except in carcinomas of the urinary bladder, where the percentage of positive sera and of sera with high titers was higher than in other groups. BKV infection is discussed in relation to its possible connection with human non-neoplastic diseases as well as with human tumors and to its activation under conditions of immunosuppressive therapy.
- Subjects :
- Male
viruses
Immunology
Biology
medicine.disease_cause
Antibodies, Viral
Microbiology
Capsid
Antigen
Antigens, Neoplasm
Neoplasms
medicine
Humans
Antigens, Viral
Urinary bladder
virus diseases
medicine.disease
Virology
Tumor antigen
BK virus
Titer
Infectious Diseases
medicine.anatomical_structure
Rheumatoid arthritis
BK Virus
biology.protein
Parasitology
Female
Antibody
Polyomavirus
Research Article
Subjects
Details
- ISSN :
- 00199567
- Volume :
- 13
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Infection and immunity
- Accession number :
- edsair.doi.dedup.....7204a4e4d9191a5d6e06bc388de6cd33