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Exposure to organochlorine pollutants and type 2 diabetes: a systematic review and meta-analysis
- Source :
- PLoS ONE, PLoS ONE, Vol 9, Iss 10, p e85556 (2014)
- Publication Year :
- 2013
-
Abstract
- Objective Though exposure to organochlorine pollutants (OCPs) is considered a risk factor for type 2 diabetes (T2DM), epidemiological evidence for the association remains controversial. A systematic review and meta-analysis was applied to quantitatively evaluate the association between exposure to OCPs and incidence of T2DM and pool the inconsistent evidence. Design and Methods Publications in English were searched in MEDLINE and WEB OF SCIENCE databases and related reference lists up to August 2013. Quantitative estimates and information regarding study characteristics were extracted from 23 original studies. Quality assessments of external validity, bias, exposure measurement and confounding were performed, and subgroup analyses were conducted to examine the heterogeneity sources. Results We retrieved 23 eligible articles to conduct this meta-analysis. OR (odds ratio) or RR (risk ratio) estimates in each subgroup were discussed, and the strong associations were observed in PCB-153 (OR, 1.52; 95% CI, 1.19ā1.94), PCBs (OR, 2.14; 95% CI, 1.53ā2.99), and p,pā²-DDE (OR, 1.33; 95% CI, 1.15ā1.54) based on a random-effects model. Conclusions This meta-analysis provides quantitative evidence supporting the conclusion that exposure to organochlorine pollutants is associated with an increased risk of incidence of T2DM.
- Subjects :
- Cross-sectional study
Epidemiology
lcsh:Medicine
Environmental pollution
Toxicology
Endocrinology
Risk Factors
Hydrocarbons, Chlorinated
Medicine and Health Sciences
Medicine
Clinical Epidemiology
lcsh:Science
Multidisciplinary
Confounding
Agriculture
Research Assessment
Pollution
Type 2 Diabetes
Systematic review
Cardiovascular Diseases
Research Design
Meta-analysis
Physical Sciences
Engineering and Technology
Type 2 Diabetes Risk
Agrochemicals
Statistics (Mathematics)
Research Article
Pollutants
Environmental Engineering
Systematic Reviews
Clinical Research Design
Toxic Agents
Cardiology
Research and Analysis Methods
Environmental Epidemiology
Environmental health
Diabetes Mellitus
Humans
Environmental Chemistry
Risk factor
Pesticides
Statistical Methods
Cardiovascular Disease Epidemiology
Diabetic Endocrinology
business.industry
lcsh:R
Ecology and Environmental Sciences
Biology and Life Sciences
Health Risk Analysis
Odds ratio
Cardiovascular Disease Risk
Lipid Metabolism
Health Care
Cross-Sectional Studies
Diabetes Mellitus, Type 2
Relative risk
Metabolic Disorders
Case-Control Studies
lcsh:Q
business
Environmental Pollution
Mathematics
Meta-Analysis
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 9
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- PloS one
- Accession number :
- edsair.doi.dedup.....72194cee4f59f2c4db69e40fa77180b7