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Association of hemodynamic factors and progressive aortic dilatation following type A aortic dissection surgical repair
- Source :
- Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021), Scientific Reports
- Publication Year :
- 2021
- Publisher :
- Nature Portfolio, 2021.
-
Abstract
- Type A aortic dissection (TAAD) involves the ascending aorta or the arch. Acute TAAD usually requires urgent replacement of the ascending aorta. However, a subset of these patients develops aortic rupture due to further dilatation of the residual dissected aorta. There is currently no reliable means to predict the risk of dilatation following TAAD repair. In this study, we performed a comprehensive morphological and hemodynamic analysis for patients with and without progressive aortic dilatation following surgical replacement of the ascending aorta. Patient-specific models of repaired TAAD were reconstructed from post-surgery computed tomography images for detailed computational fluid dynamic analysis. Geometric and hemodynamic parameters were evaluated and compared between patients with stable aortic diameters (N = 9) and those with aortic dilatation (N = 8). Our results showed that the number of re-entry tears and true/false lumen pressure difference were significantly different between the two groups. Patients with progressive aortic dilatation had higher luminal pressure difference (6.7 [4.6, 10.9] vs. 0.9 [0.5, 2.3] mmHg; P = 0.001) and fewer re-entry tears (1.5 [1, 2.8] vs. 5 [3.3, 7.5]; P = 0.02) compared to patients with stable aortic diameters, suggesting that these factors may serve as potential predictors of aneurysmal dilatation following surgical repair of TAAD.
- Subjects :
- Male
medicine.medical_specialty
Mathematics and computing
Science
0206 medical engineering
Cardiology
Hemodynamics
Diseases
Aorta, Thoracic
02 engineering and technology
030204 cardiovascular system & hematology
Article
03 medical and health sciences
Engineering
0302 clinical medicine
medicine.artery
Internal medicine
Ascending aorta
Humans
Medicine
Aortic rupture
Aortic dilatation
Surgical repair
Aortic dissection
Aorta
Multidisciplinary
Aortic Aneurysm, Thoracic
business.industry
Models, Cardiovascular
medicine.disease
020601 biomedical engineering
Aortic Dissection
cardiovascular system
Tears
Female
business
Dilatation, Pathologic
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 11
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....7223e2c405535610a998fcc6922b8799