JC virus granule cell neuronopathy associated with Ruxolitinib: A case report and review of the literature

Authors :: Satoshi Kaneko
Masayuki Saijo
Hirofumi Kusaka
Akiko Konishi
Masataka Nakamura
Kentaro Nakayama
Kazuo Nakamichi
Yusuke Yakushiji
Source :: eNeurologicalSci, Vol 21, Iss, Pp 100269-(2020), eNeurologicalSci
Publication Year :: 2020
Publisher :: Elsevier, 2020.
Abstract: Highlights • We report here a case of JC virus granule cell neuronopathy associated with Ruxolitinib • It is worthwhile considering the possibility of JCV-GCN in myelofibrosis patients receiving ruxiolitinib, who present with progressive cerebellar symptoms and cerebellar atrophy. • Combination therapy using mefloquine and mirtazapine may be an effective treatment.

Tools