Back to Search
Start Over
Langerhans cell related inflammatory reaction in laryngeal squamous cell carcinoma
- Source :
- Auris, nasus, larynx. 30(1)
- Publication Year :
- 2003
-
Abstract
- The major cells involved in cancer cell kill are the T lymphocytes. However, T cells need to be activated upon antigen presentation, which is mediated by the antigen presenting cells, one of which is the Langerhans cell (LC). The purpose of this study was to assess the significance of LC and inflammatory cell infiltration in the laryngeal squamous cell carcinoma (LSCC). Forty-five patients who were operated on for LSCC between 1992 and 1999 were included in the study. The clinical and histopathological features of the patients were reviewed. A semiquantitative estimation of the lymphocyte dominant inflammatory reaction within and around the tumor was performed. Anti S-100 antibodies were used for immunohistochemical detection of LCs. Horseradish peroxidase method was used. LCs were present in almost all of the specimens within and around the tumor tissue. The S-100 results did not associate with grade, T and N stages, tumor stage, laryngeal site of involvement and survival (P>0.05). The S-100 results significantly associated with inflammatory reaction in the tumor tissue (P
- Subjects :
- Adult
Male
Pathology
medicine.medical_specialty
Langerhans cell
Lymphocyte
Antigen presentation
Metastasis
Medicine
Humans
Antigen-presenting cell
Laryngeal Neoplasms
Aged
Neoplasm Staging
Analysis of Variance
biology
business.industry
S100 Proteins
Antibodies, Monoclonal
General Medicine
Middle Aged
medicine.disease
Immunohistochemistry
medicine.anatomical_structure
Otorhinolaryngology
Langerhans Cells
Cancer cell
biology.protein
Carcinoma, Squamous Cell
Surgery
Female
Antibody
business
Subjects
Details
- ISSN :
- 03858146
- Volume :
- 30
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Auris, nasus, larynx
- Accession number :
- edsair.doi.dedup.....7236f1906e0fb2b169586a989bee67b8