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Hormone Receptor Subtype in Ductal Carcinoma in Situ: Prognostic and Predictive Roles of the Progesterone Receptor
- Source :
- The Oncologist
- Publication Year :
- 2021
- Publisher :
- John Wiley & Sons, Inc., 2021.
-
Abstract
- Background We investigated the prognostic and predictive roles of the hormone receptor (HRc) subtype in patients with ductal carcinoma in situ (DCIS). We focused on identifying the roles of the progesterone receptor (PR) independent of estrogen receptor (ER) status. Methods Nationwide data of 12,508 female patients diagnosed with DCIS with a mean follow‐up period of 60.7 months were analyzed. HRc subtypes were classified as ER−/PR−, ER−/PR+, ER+/PR−, and ER+/PR+ based on ER and PR statuses. The Cox proportional hazards model was used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs). Results The ER+/PR+ group showed better prognoses than the ER+/PR− and ER−/PR− groups in the patients who received tamoxifen therapy (p = .001 and p = .031, respectively). HRc subtype was an independent prognostic factor (p = .028). The tamoxifen therapy group showed better survival than the patients who did not receive tamoxifen, but only in the ER+/PR+ subgroup (p = .002). Tamoxifen therapy was an independent prognostic factor (HR, 0.619; 95% CI, 0.423 − 0.907; p = .014). PR status was a favorable prognostic factor in patients with DCIS who received tamoxifen therapy (p<br />This study investigated the prognostic and predictive roles of the hormone receptor subtype in patients with newly diagnosed ductal carcinoma in situ, focusing on the prognostic and predictive values of progesterone receptor status independent of estrogen receptor status. The prognostic effect of tamoxifen therapy was also investigated
- Subjects :
- Oncology
Cancer Research
medicine.medical_specialty
Estrogen receptor
Progesterone receptor
Internal medicine
Breast Cancer
medicine
Humans
skin and connective tissue diseases
Predictive marker
business.industry
Proportional hazards model
Hazard ratio
Ductal carcinoma in situ
Ductal carcinoma
Prognosis
Hormones
Hormone receptor subtype
Carcinoma, Intraductal, Noninfiltrating
Hormone receptor
Female
Breast neoplasms
business
Receptors, Progesterone
Tamoxifen
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 1549490X and 10837159
- Volume :
- 26
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- The Oncologist
- Accession number :
- edsair.doi.dedup.....724404f08bb2b7d4c6d2a5f52ecf5ce2