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A comparative study on demographic, hematological, and cytogenetic findings and prognosis in acute myeloid leukemia with and without leukemia cutis
- Source :
- Annals of Hematology. 81:90-95
- Publication Year :
- 2002
- Publisher :
- Springer Science and Business Media LLC, 2002.
-
Abstract
- We studied the incidence of leukemia cutis (LC) in 381 consecutive patients with acute myeloid leukemia (AML) in a single institution and compared the demographic, hematological, and cytogenetic findings in AML patients with and without LC. We also examined the response to intensive chemotherapy, overall survival, and duration of remission in this patient population with regard to the presence of LC. The prevalence of LC was 3.7% in clinically diagnosed patients and 2.9% in biopsy-proven cases, respectively. Patients with and without LC did not differ with regard to age, sex, white blood cell counts, hemoglobin, fibrinogen, and platelet counts at diagnosis, but lactate dehydrogenase (LDH) was significantly higher in patients with LC. Various karyotype abnormalities were found, but in patients with LC numerical abnormalities of chromosome 8 were significantly more common ( P0.0001). Patients with LC did not differ from patients without LC with regard to remission rate, but there was a trend towards shorter remission duration in patients with LC. We conclude that patients with LC have some features different from patients without this symptom. The increased frequency of numerical aberrations of chromosome 8 in patients with LC was the most interesting observation of our study. The pathophysiological significance of this finding remains to be determined.
- Subjects :
- Adult
Male
medicine.medical_specialty
Pathology
Gastroenterology
chemistry.chemical_compound
Sex Factors
Lactate dehydrogenase
White blood cell
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
medicine
Humans
Aged
Chromosome Aberrations
Leukemia
Hematology
business.industry
Incidence
Incidence (epidemiology)
Remission Induction
Age Factors
Cytogenetics
Myeloid leukemia
Leukemia cutis
General Medicine
Middle Aged
Survival Analysis
medicine.anatomical_structure
chemistry
Leukemia, Myeloid
Female
medicine.symptom
business
Complication
Chromosomes, Human, Pair 8
Subjects
Details
- ISSN :
- 14320584 and 09395555
- Volume :
- 81
- Database :
- OpenAIRE
- Journal :
- Annals of Hematology
- Accession number :
- edsair.doi.dedup.....7260c6066c70f040cec3f566fec1360a
- Full Text :
- https://doi.org/10.1007/s00277-001-0412-9