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Depression-like behavior in the forced swimming test in PACAP-deficient mice: amelioration by the atypical antipsychotic risperidone
- Source :
- Journal of Neurochemistry. 110:595-602
- Publication Year :
- 2009
- Publisher :
- Wiley, 2009.
-
Abstract
- Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide with pleiotropic functions. We report here that PACAP-deficient (PACAP-/-) mice showed increased immobility in a forced swimming test, which was reduced by the antidepressant desipramine, to a similar extent as in wild-type mice. The atypical antipsychotic risperidone and the selective serotonin (5-HT)(2) antagonist ritanserin normalized the depression-like behavior in PACAP-/- mice. The 5-HT(2) agonist (+/-)-2,5-dimethoxy-4-iodoamphetamine-induced 5-HT syndrome was exaggerated in PACAP-/- mice, which suggests a 5-HT(2)-receptor-dependent mechanism in the depression-like behavior. The circadian rhythm of plasma corticosterone and body core temperature was significantly flattened in the mutants. mRNA expression of glucocorticoid receptor was reduced in the mutant hippocampus. The present results suggest that alterations in PACAP signaling might contribute to the pathogenesis of certain depressive conditions amenable to atypical antipsychotic drugs.
- Subjects :
- Male
Agonist
endocrine system
medicine.medical_specialty
medicine.drug_class
Atypical antipsychotic
Ritanserin
Biochemistry
Body Temperature
Mice
Cellular and Molecular Neuroscience
Receptors, Glucocorticoid
Desipramine
Internal medicine
medicine
Animals
RNA, Messenger
Swimming
Mice, Knockout
Risperidone
Depression
business.industry
Circadian Rhythm
Pituitary adenylate cyclase-activating peptide
Endocrinology
Mutation
Pituitary Adenylate Cyclase-Activating Polypeptide
Serotonin
Corticosterone
business
hormones, hormone substitutes, and hormone antagonists
Antipsychotic Agents
Behavioural despair test
medicine.drug
Subjects
Details
- ISSN :
- 14714159 and 00223042
- Volume :
- 110
- Database :
- OpenAIRE
- Journal :
- Journal of Neurochemistry
- Accession number :
- edsair.doi.dedup.....72615e171cbe6c65823b3d48101e1bea
- Full Text :
- https://doi.org/10.1111/j.1471-4159.2009.06168.x