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Bioactivity of food peptides: biological response of rats to bovine milk whey peptides following acute exercise
- Source :
- Food & Nutrition Research
- Publication Year :
- 2016
-
Abstract
- Background: Several physiologically beneficial effects of consuming a whey protein hydrolysate (WPH) have been attributed to the greater availability of bioactive peptides. Aims: The aim was to investigate the effect of four branched-chain amino acid- (BCAA-)containing dipeptides, present in WPH, on immune modulation, stimulation of HSP expression, muscle protein synthesis, glycogen content, satiety signals and the impact of these peptides on the plasma free amino acid profiles. Methods: The animals were divided in groups: control (rest, without gavage), vehicle (water), L-isoleucyl-L-leucine (lle-Leu), L-leucyl-L-isoleucine (Leu-lle), L-valyl-Lleucine (Val-Leu), L-leucyl-L-valine (Leu-Val) and WPH. All animals were submitted to acute exercise, except for control. Results: lle-Leu stimulated immune response, hepatic and muscle glycogen and HSP60 expression, whereas Leu-Val enhanced HSP90 expression. All dipeptides reduced glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide, no changes were observed on leptin. All peptides inhibited NF-kB expression. The plasma amino acid time-course showed peptide-specific and isomer-specific metabolic features, including increases of the BCAAs. Conclusion: The data indicate that lle-Leu was effective to attenuate immune-suppression exercise-induced, promoted glycogen content and stimulated anti-stress effect (HSP). Furthermore, Leu-Val increased HSP90, p-4EBP1, p-mTOR and p-AMPK expression. The data suggest the involvement of these peptides in various beneficial functions of WPH consumption.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Stimulation
Hydrolysate
03 medical and health sciences
chemistry.chemical_compound
Immune system
Internal medicine
medicine
HSP
whey protein hydrolysate
Bioactive peptides
chemistry.chemical_classification
030109 nutrition & dietetics
Nutrition and Dietetics
biology
Glycogen
Leptin
Public Health, Environmental and Occupational Health
Hsp90
Amino acid
030104 developmental biology
Endocrinology
chemistry
glycogen
biology.protein
HSP60
Original Article
immune
Food Science
Subjects
Details
- ISSN :
- 1654661X
- Volume :
- 61
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Foodnutrition research
- Accession number :
- edsair.doi.dedup.....726ed6edeefd3d9c3e22a25c16f333ce