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ZFAT is an antiapoptotic molecule and critical for cell survival in MOLT‐4 cells

Authors :
Senji Shirasawa
Yasuo Takashima
Midori Koyanagi
Takehiko Sasazuki
Takahiro Fujimoto
Toshiyuki Tsunoda
Keiko Doi
Yasuhiro Yoshida
Source :
FEBS Letters. 583:568-572
Publication Year :
2009
Publisher :
Wiley, 2009.

Abstract

ZFAT (also known as ZNF406), originally identified as a candidate gene for autoimmune thyroid disease, encodes a zinc-finger protein, however, its function has not been elucidated. Here, we report that human ZFAT protein is expressed in peripheral B and T lymphocytes and a human acute T lymphoblastic leukaemia cell line, MOLT-4 cells. Intriguing is that mouse ZFAT expression in CD4+ lymphocytes is increased during blast formation. Furthermore, ZFAT-knockdown in MOLT-4 induces apoptosis via activation of caspases. These results suggested that ZFAT protein is a critical regulator involved in apoptosis and cell survival for immune-related cells.

Details

ISSN :
18733468 and 00145793
Volume :
583
Database :
OpenAIRE
Journal :
FEBS Letters
Accession number :
edsair.doi.dedup.....727933de25a5dd7567a334314c47feeb
Full Text :
https://doi.org/10.1016/j.febslet.2008.12.063