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ZFAT is an antiapoptotic molecule and critical for cell survival in MOLT‐4 cells
- Source :
- FEBS Letters. 583:568-572
- Publication Year :
- 2009
- Publisher :
- Wiley, 2009.
-
Abstract
- ZFAT (also known as ZNF406), originally identified as a candidate gene for autoimmune thyroid disease, encodes a zinc-finger protein, however, its function has not been elucidated. Here, we report that human ZFAT protein is expressed in peripheral B and T lymphocytes and a human acute T lymphoblastic leukaemia cell line, MOLT-4 cells. Intriguing is that mouse ZFAT expression in CD4+ lymphocytes is increased during blast formation. Furthermore, ZFAT-knockdown in MOLT-4 induces apoptosis via activation of caspases. These results suggested that ZFAT protein is a critical regulator involved in apoptosis and cell survival for immune-related cells.
- Subjects :
- Candidate gene
Cell Survival
Biophysics
Regulator
Apoptosis
Biochemistry
Mice
Enzyme activator
ZFAT
Structural Biology
Cell Line, Tumor
hemic and lymphatic diseases
Genetics
Animals
Humans
Protease Inhibitors
RNA, Small Interfering
Molecular Biology
Caspase
Zinc finger
MOLT-4
biology
RNA
Cell Biology
Caspase Inhibitors
Molecular biology
Cell biology
Enzyme Activation
Cell culture
Caspases
biology.protein
Zinc-finger protein
Transcription Factors
Subjects
Details
- ISSN :
- 18733468 and 00145793
- Volume :
- 583
- Database :
- OpenAIRE
- Journal :
- FEBS Letters
- Accession number :
- edsair.doi.dedup.....727933de25a5dd7567a334314c47feeb
- Full Text :
- https://doi.org/10.1016/j.febslet.2008.12.063