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Analysis of GM-CSF gene polymorphisms (3606T/C and 3928C/T) in Japanese patients with atopic dermatitis
- Source :
- Clinical and experimental dermatology. 31(2)
- Publication Year :
- 2006
-
Abstract
- Granulocyte-macrophage colony-stimulating factor (GM-CSF) is thought to play an important role in the pathogenesis of atopic dermatitis. To examine whether GM-CSF single nucleotide polymorphisms (SNPs) are associated with susceptibility to atopic dermatitis, we investigated the genotype and allele frequencies of the SNPs 3606T/C and 3928C/T of the GM-CSF gene in 181 Japanese patients with atopic dermatitis and 100 controls, using a PCR restriction fragment length polymorphism method. A strong linkage disequilibrium existed between the polymorphisms 3606 and 3928, suggesting two common GM-CSF haplotypes, 3606*T-3928*C and 3606*C-3928*T. However, there was no significant difference in genotype or allele frequencies between patients with atopic dermatitis and controls for either of the two polymorphisms, thus GM-CSF SNPs do not appear to be associated with susceptibility to atopic dermatitis in Japanese patients. A large-scale study is necessary to confirm these findings.
- Subjects :
- Adult
Male
Allergy
Linkage disequilibrium
Adolescent
Single-nucleotide polymorphism
Dermatology
Polymorphism, Single Nucleotide
Dermatitis, Atopic
Atopy
Japan
Genotype
medicine
Humans
Child
Allele frequency
Genetics
Polymorphism, Genetic
business.industry
Haplotype
Granulocyte-Macrophage Colony-Stimulating Factor
Atopic dermatitis
Middle Aged
medicine.disease
body regions
Case-Control Studies
Immunology
Female
business
Subjects
Details
- ISSN :
- 03076938
- Volume :
- 31
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Clinical and experimental dermatology
- Accession number :
- edsair.doi.dedup.....727ef0068764049211e66948feca9d28