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Impact of low-density lipoprotein cholesterol on decline in estimated glomerular filtration rate in apparently healthy young to middle-aged working men
- Source :
- Clinical and experimental nephrology. 22(1)
- Publication Year :
- 2017
-
Abstract
- It remains to be fully clarified whether there is a relationship between uncontrolled dyslipidemia and decline in estimated glomerular filtration rate (eGFR) in the general population. Therefore, this study’s aim was to test the association of dyslipidemia with changes in eGFR in apparently healthy working men. We retrospectively examined the annual medical check-up list of 14,510 male workers aged 20–60 years with eGFR ≥ 60 mL/min/1.73 m2 at baseline, and then evaluated the association of the changes in the check-up parameters with a decline in eGFR during the 5-year observation period. Mean age and eGFR were 38.5 years and 82.3 mL/min/1.73 m2 at baseline, respectively. Evaluated low-density lipoprotein cholesterol (LDL-C) (≥140 mg/dL) was a strong indicator of CKD development in participants (basal eGFR 60–90 mL/min/1.73 m2) without hypertension [odds ratio (95% confidence interval): 1.46 (1.12–1.90)] or diabetes mellitus (DM) [1.49 (1.23–1.82)]. When LDL-C normalized under 140 mg/dL during follow-up, the decline in eGFR was smaller in non-hypertensive participants [−5.9 (−14.4 to −0.9) vs −13.4 (−18.4 to −4.5) mL/min/1.73 m2, p
- Subjects :
- Adult
Male
medicine.medical_specialty
Physiology
Population
030232 urology & nephrology
Renal function
030204 cardiovascular system & hematology
Gastroenterology
03 medical and health sciences
Young Adult
0302 clinical medicine
Japan
Reference Values
Risk Factors
Physiology (medical)
Internal medicine
Diabetes mellitus
medicine
Humans
Young adult
Renal Insufficiency, Chronic
education
Occupational Health
Dyslipidemias
Retrospective Studies
education.field_of_study
business.industry
Odds ratio
Cholesterol, LDL
Middle Aged
medicine.disease
Confidence interval
Endocrinology
Nephrology
Metabolic syndrome
business
Dyslipidemia
Glomerular Filtration Rate
Subjects
Details
- ISSN :
- 14377799
- Volume :
- 22
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Clinical and experimental nephrology
- Accession number :
- edsair.doi.dedup.....7297bab1b56359a502991ea331c94cb4