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Proton beam therapy delivered using pencil beam scanning vs. passive scattering/uniform scanning for localized prostate cancer: Comparative toxicity analysis of PCG 001-09
- Source :
- Clinical and Translational Radiation Oncology, Clinical and Translational Radiation Oncology, Vol 19, Iss, Pp 80-86 (2019)
- Publication Year :
- 2019
-
Abstract
- Highlights • Benefits of proton beam therapy for treatment of prostate cancer are unknown. • Data comparing pencil beam vs. passive scatter/uniform scanning protons are limited. • Significant differences in acute toxicity between proton modalities were observed. • Future studies evaluating differences between the two proton modalities are needed.<br />Background and purpose Patient-level benefits of proton beam therapy (PBT) relative to photon therapy for prostate cancer (PC) continue to be the focus of debate. Although trials comparing the two modalities are underway, most are being conducted using “conventional” PBT (passive scattering/uniform scanning [PS/US]) rather than pencil beam scanning (PBS). The dosimetric benefits of PBS are well-known, but comparative data are limited. This analysis compares PBS toxicity rates with those of PS/US in a prospective multicenter registry. Methods We evaluated acute/late gastrointestinal (GI) and genitourinary (GU) toxicity rates for men with low-to-intermediate risk PC enrolled in PCG 001-09. Acute toxicities with the two techniques were compared using χ2 tests, and the cumulative incidence methods for late toxicity. Multivariable analyses (MVAs) for acute toxicity were performed using logistic regression, and cox proportional hazards models for late toxicity. Results Patients were treated using PS/US (n = 1105) or PBS (n = 238). Acute grade ≥2 GI toxicity in PBS did not significantly differ from that with PS/US (2.9% and 2.1%, respectively; P = 0.47). Acute grade ≥2 GU toxicity was significantly higher with PBS (21.9% and 15.1%; P
- Subjects :
- genetic structures
Quantitative Biology::Tissues and Organs
PC, prostate cancer
medicine.medical_treatment
Nuclear Theory
Physics::Medical Physics
R895-920
PS/US, passive scattering/uniform scanning
Article
PCG, Proton Collaborative Group
Pencil beam scanning
030218 nuclear medicine & medical imaging
Medical physics. Medical radiology. Nuclear medicine
03 medical and health sciences
Prostate cancer
0302 clinical medicine
medicine
Radiology, Nuclear Medicine and imaging
Cumulative incidence
Nuclear Experiment
PARTIQoL, Prostate Advanced Radiation Technologies Investigating Quality of Life
Pencil-beam scanning
Proton therapy
RC254-282
business.industry
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Common Terminology Criteria for Adverse Events
RT, radiation therapy
MVA, multivariable analysis
GI, gastrointestinal
medicine.disease
Acute toxicity
PBT, proton beam therapy
Radiation therapy
Passive scattering, uniform scanning
Comparative effectiveness, Toxicity
Oncology
030220 oncology & carcinogenesis
Toxicity
Physics::Accelerator Physics
CTCAE, Common Terminology Criteria for Adverse Events
GU, genitourinary
RBE, relative biological effectiveness
LET, linear energy transfer
Nuclear medicine
business
PBS, pencil beam scanning
Subjects
Details
- ISSN :
- 24056308
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Clinical and translational radiation oncology
- Accession number :
- edsair.doi.dedup.....72a39f4f1013f9d8a9b194aad0504130