Back to Search
Start Over
The role of microRNA in esophageal squamous cell carcinoma
- Source :
- Journal of Gastroenterology. 51:520-530
- Publication Year :
- 2016
- Publisher :
- Springer Science and Business Media LLC, 2016.
-
Abstract
- MicroRNAs (miRNA) are 22-nucleotide non-coding RNAs that post-transcriptionally regulate gene expression by base pairing to partially complementary sequences in the 3'-untranslated region of their target messenger RNA. Altered miRNA expression also changes the expression of oncogenes and tumor suppressors, affecting the proliferation, apoptosis, motility and invasibility of gastrointestinal cancer cells, including the cells of esophageal squamous cell carcinoma (ESCC). It has been suggested that various miRNA expression profiles may provide useful biomarkers and therapeutic targets, but to date few studies have been published on the role of miRNA in ESCC. In this review we summarize the identification and characterization of miRNAs involved in ESCC and discuss their potential as biomarkers and therapeutic targets.
- Subjects :
- 0301 basic medicine
Esophageal Neoplasms
Motility
Biology
Bioinformatics
law.invention
03 medical and health sciences
0302 clinical medicine
Surgical oncology
law
microRNA
Gene expression
medicine
Humans
Gastrointestinal cancer
Messenger RNA
Gastroenterology
medicine.disease
MicroRNAs
030104 developmental biology
Apoptosis
030220 oncology & carcinogenesis
Carcinoma, Squamous Cell
Cancer research
Suppressor
Esophageal Squamous Cell Carcinoma
Subjects
Details
- ISSN :
- 14355922 and 09441174
- Volume :
- 51
- Database :
- OpenAIRE
- Journal :
- Journal of Gastroenterology
- Accession number :
- edsair.doi.dedup.....72ac57aeb82ae0bf322dbcbb72f389c7