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Therapeutic potential of dental pulp stem cell transplantation in a rat model of Alzheimer’s disease

Authors :
Ying Shi
Xue-Mei Zhang
Dan Yang
Na Li
Duo Wang
Wei Li
Jin Fu
Bing-Qian Yu
Yuan-Jiao Ouyang
Yun-Yun Xu
Zhuo-Min Jiao
Hui Yue
Mei-Yu Yu
Jin-Yue Li
Zhi-Jun He
Source :
Neural Regeneration Research, Vol 16, Iss 5, Pp 893-898 (2021), Neural Regeneration Research
Publication Year :
2021
Publisher :
Wolters Kluwer Medknow Publications, 2021.

Abstract

Dental pulp stem cells are dental pulp-derived mesenchymal stem cells that originate from the neural crest. They exhibit greater potential for the treatment of nervous system diseases than other types of stem cells because of their neurogenic differentiation capability and their ability to secrete multiple neurotrophic factors. Few studies have reported Alzheimer's disease treatment using dental pulp stem cells. Rat models of Alzheimer's disease were established by injecting amyloid-β1-42 into the hippocampus. Fourteen days later, 5 × 106 dental pulp stem cells were injected into the hippocampus. Immunohistochemistry and western blot assays showed that dental pulp stem cell transplantation increased the expression of neuron-related doublecortin, NeuN, and neurofilament 200 in the hippocampus, while the expression of amyloid-β was decreased. Moreover, cognitive and behavioral abilities were improved. These findings indicate that dental pulp stem cell transplantation in rats can improve cognitive function by regulating the secretion of neuron-related proteins, which indicates a potential therapeutic effect for Alzheimer's disease. This study was approved by the Animal Ethics Committee of Harbin Medical University, China (approval No. KY2017-132) on February 21, 2017.

Details

Language :
English
ISSN :
16735374
Volume :
16
Issue :
5
Database :
OpenAIRE
Journal :
Neural Regeneration Research
Accession number :
edsair.doi.dedup.....72ae0bae3d0315e01aa24285a4f0facf