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Life‐Course Reproductive History and Cardiovascular Risk Profile in Late Mid‐Life: The CARDIA Study
- Source :
- Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
- Publication Year :
- 2020
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2020.
-
Abstract
- Background Reproductive events, that is, a preterm birth ( PTB ), small‐for‐gestational‐age infant ( SGA ), and vasomotor symptoms of menopause, are associated with subclinical atherosclerotic cardiovascular disease ( ASCVD ). We evaluated whether women with a past PTB and/or SGA (henceforth PTB / SGA ) were more likely to have severe vasomotor symptoms of menopause and whether the estimated 10‐year ASCVD risk was higher in women with PTB / SGA and vasomotor exposures. Methods and Results We assigned 1866 women (mean age=55±1 years) in the CARDIA (Coronary Artery Risk Development in Young Adults) study to the following categories of reproductive exposures: none, PTB / SGA only, vasomotor symptoms only, or both PTB / SGA and vasomotor symptoms. We used Kruskal‐Wallis tests to evaluate the differences in pooled cohort equation ASCVD risk scores by category and linear regression to evaluate the associations of categories with ASCVD risk scores adjusted for study center, body mass index , education, current hormone replacement therapy use, parity, and hysterectomy. Women with PTB / SGA were more likely to have severe vasomotor symptoms, 36% versus 30%, P ASCVD risk score was higher in women with both PTB / SGA and vasomotor symptoms (4.6%; 95% CI, 4.1%–5.1%) versus women with no exposures (3.3%; 95% CI , 2.9%–3.7%) or vasomotor symptoms only (3.8%; 95% CI , 3.5%–4.0%). ASCVD risk score was higher in women PTB / SGA (4.8%; 95% CI , 3.6%–5.9%) versus no exposures. PTB / SGA and vasomotor symptoms was associated with ASCVD risk score in white women versus no exposures (β=0.40; 95% CI, 0.02–0.78). Conclusions Women with prior PTB / SGA were more likely to have severe vasomotor symptoms of menopause. Reproductive exposures were associated with an estimated 10‐year ASCVD risk in white women.
- Subjects :
- medicine.medical_specialty
Time Factors
adverse pregnancy outcomes
Epidemiology
menopause
Gestational Age
Sweating
macromolecular substances
030204 cardiovascular system & hematology
Risk Assessment
Risk profile
White People
03 medical and health sciences
Sex Factors
0302 clinical medicine
Risk Factors
Pregnancy
Birth Weight
Humans
Reproductive history
Medicine
Women
Longitudinal Studies
CVD risk factors
Original Research
Subclinical infection
030219 obstetrics & reproductive medicine
integumentary system
Vasomotor
business.industry
Obstetrics
Infant, Newborn
Middle Aged
Atherosclerosis
Prognosis
medicine.disease
United States
Race Factors
Black or African American
Vasomotor System
Menopause
Hot Flashes
Infant, Small for Gestational Age
Premature Birth
Life course approach
Female
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 20479980
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Journal of the American Heart Association
- Accession number :
- edsair.doi.dedup.....72e254cb432d101af35faabcef005303