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Cannabinoid Type 1 Receptor Gene Polymorphism and Macronutrient Intake
Cannabinoid Type 1 Receptor Gene Polymorphism and Macronutrient Intake
- Publication Year :
- 2012
-
Abstract
- Background: Cannabinoid type 1 receptor (CB1-R) is a key mediator in the control of food intake and is linked to obesity. Aim: To evaluate the relationship between CB1-R gene polymorphism and dietary macronutrient intake in elderly subjects. Methods: This study included 118 subjects (60 males, 58 females) from a population survey carried out in southern Italy in 1992–1993 who were older than 65 years and previously characterized for CB1-R polymorphism (75 with GG wild-type genotype, 41 with heterozygous polymorphic allele AG, and 2 with genotype AA). All subjects completed a validated semi-quantitative food frequency questionnaire. Statistical methods included multiple logistic regression to model macronutrient intake to genotype, controlling for potential confounders. Results: When controlled for age, gender, and body mass index, the intake of dietary cholesterol and saturated fats corrected for calories was inversely associated with the CB1-R 1359 G/A polymorphism, while the intake of starchy carbohydrates was directly associated with this polymorphism. Conclusion: In our unselected elderly population, the 1359 G/A polymorphism is linked with a specific macronutrient intake. This could be explained by the role of the cannabinoid system as a determinant of food intake and eating behavior.
- Subjects :
- Adult
Male
medicine.medical_specialty
Food intake
Cannabinoid receptor
Genotype
medicine.medical_treatment
Medicine (miscellaneous)
Biology
Diet Surveys
Polymorphism, Single Nucleotide
Eating
Food Preferences
Mediator
Receptor, Cannabinoid, CB1
Internal medicine
Surveys and Questionnaires
Genetics
medicine
Humans
Longitudinal Studies
Receptor
Aged
digestive, oral, and skin physiology
Middle Aged
medicine.disease
Obesity
Endocrinology
lipids (amino acids, peptides, and proteins)
Female
Gene polymorphism
Cannabinoid
Food Science
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....7308889ebd8f090cb53a77b2ea3979ac