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Impact of Resveratrol on Glucose Control, Hippocampal Structure and Connectivity, and Memory Performance in Patients with Mild Cognitive Impairment
- Source :
- Frontiers in Neuroscience 11 (2017), Frontiers in Neuroscience
- Publication Year :
- 2017
- Publisher :
- Frontiers Media SA, 2017.
-
Abstract
- In healthy older adults, resveratrol supplementation has been shown to improve long-term glucose control, resting-state functional connectivity (RSFC) of the hippocampus, and memory function. Here, we aimed to investigate if these beneficial effects extend to individuals at high-risk for dementia, i.e., patients with mild cognitive impairment (MCI). In a randomized, double-blind interventional study, 40 well-characterized patients with MCI (21 females; 50–80 years) completed 26 weeks of resveratrol (200 mg/d; n = 18) or placebo (1,015 mg/d olive oil; n = 22) intake. Serum levels of glucose, glycated hemoglobin A1c and insulin were determined before and after intervention. Moreover, cerebral magnetic resonance imaging (MRI) (3T) (n = 14 vs. 16) was conducted to analyze hippocampus volume, microstructure and RSFC, and neuropsychological testing was conducted to assess learning and memory (primary endpoint) at both time points. In comparison to the control group, resveratrol supplementation resulted in lower glycated hemoglobin A1c concentration with a moderate effect size (ANOVARM p = 0.059, Cohen's d = 0.66), higher RSFC between right anterior hippocampus and right angular cortex (p < 0.001), and led to a moderate preservation of left anterior hippocampus volume (ANOVARM p = 0.061, Cohen's d = 0.68). No significant differences in memory performance emerged between groups. This proof-of-concept study indicates for the first-time that resveratrol intake may reduce glycated hemoglobin A1c, preserves hippocampus volume, and improves hippocampus RSFC in at-risk patients for dementia. Larger trials with longer intervention time should now determine if these benefits can be validated and extended to cognitive function. DFG/Fl 379-10/1 DFG/Fl 379-11/1 DFG/EXC/257 BMBF/FKZ 0315673A BMBF/01EO0801 BMBF/01GQ1424A BMBF/01GQ1420B
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
hippocampus
resting-state functional connectivity
medicine.medical_treatment
Hippocampus
resveratrol
Resveratrol
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
Placebo
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
medicine
Clinical endpoint
Dementia
ddc:610
Dewey Decimal Classification::500 | Naturwissenschaften
memory performance
Original Research
Resting-state functional connectivity
medicine.diagnostic_test
General Neuroscience
Insulin
Magnetic resonance imaging
Cognition
medicine.disease
MCI
Memory performance
030104 developmental biology
Endocrinology
chemistry
ddc:500
Psychology
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 1662453X
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Frontiers in Neuroscience
- Accession number :
- edsair.doi.dedup.....7312a981e822c8014fe893e35bdfd331