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Clinical comparative analysis of histidine-tryptophan-ketoglutarate solution and St. Thomas crystalloid cardioplegia: A 12-year study from a single institution
- Source :
- Experimental and therapeutic medicine. 14(3)
- Publication Year :
- 2015
-
Abstract
- Cardioplegic reperfusion during a long-term ischemic period interrupts cardiac surgery and increases cellular edema due to repeated administration. The present clinical study compared the protective effects of histidine-ketoglutarate-tryptophan (HTK) solution and St. Thomas crystalloid cardioplegia. Clinical experiences of the myocardial protection induced by one single perfusion with HTK were reviewed in high-risk patients with severe pulmonary arterial hypertension associated with complex congenital heart disease. This retrospective study included 88 high-risk patients (aortic cross-clamp time, >120 min) between March 2001 and July 2012. The cohort was divided into two groups according to the technique used. Either myocardial protection was performed with one single perfusion with HTK solution (HTK group) or with conventional St. Thomas crystalloid cardioplegia (St group). The duration of cardiopulmonary bypass did not differ between the two groups. The mortality, morbidity, intensive care unit (ICU) stay, postoperative hospitalization, and transfusions of HTK group are significantly lower than those of the St group (P
- Subjects :
- Cancer Research
medicine.medical_specialty
business.industry
Retrospective cohort study
General Medicine
Articles
030204 cardiovascular system & hematology
Intensive care unit
law.invention
Surgery
Cardiac surgery
Histidine-tryptophan-ketoglutarate
03 medical and health sciences
0302 clinical medicine
030228 respiratory system
Immunology and Microbiology (miscellaneous)
law
Edema
Anesthesia
Cohort
Cardiopulmonary bypass
Medicine
medicine.symptom
business
Perfusion
Subjects
Details
- ISSN :
- 17920981
- Volume :
- 14
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Experimental and therapeutic medicine
- Accession number :
- edsair.doi.dedup.....731484f99f3157cda8c39d4df4ab2f01