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Class A and C GPCR Dimers in Neurodegenerative Diseases

Authors :
Irina S. Moreira
Ana B. Caniceiro
Beatriz Bueschbell
Anke C. Schiedel
Source :
Current Neuropharmacology. 20:2081-2141
Publication Year :
2022
Publisher :
Bentham Science Publishers Ltd., 2022.

Abstract

Abstract: Neurodegenerative diseases affect over 30 million people worldwide with an ascending trend. Most individuals suffering from these irreversible brain damages belong to the elderly population, with onset between 50 and 60 years. Although the pathophysiology of such diseases is partially known, it remains unclear upon which point a disease turns degenerative. Moreover, current therapeutics can treat some of the symptoms but often have severe side effects and become less effective in long-term treatment. For many neurodegenerative diseases, the involvement of G proteincoupled receptors (GPCRs), which are key players of neuronal transmission and plasticity, has become clearer and holds great promise in elucidating their biological mechanism. With this review, we introduce and summarize class A and class C GPCRs, known to form heterodimers or oligomers to increase their signalling repertoire. Additionally, the examples discussed here were shown to display relevant alterations in brain signalling and had already been associated with the pathophysiology of certain neurodegenerative diseases. Lastly, we classified the heterodimers into two categories of crosstalk, positive or negative, for which there is known evidence.

Details

ISSN :
1570159X
Volume :
20
Database :
OpenAIRE
Journal :
Current Neuropharmacology
Accession number :
edsair.doi.dedup.....73187667460061ba5d31edbffac17907
Full Text :
https://doi.org/10.2174/1570159x20666220327221830