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Synthesis of carbon-11 labelled glycine and the dipeptides L-phenylalanylglycine and L-leucylglycine
- Source :
- International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes. 37(9)
- Publication Year :
- 1986
-
Abstract
- Carbon-11 labelled glycine has been prepared in 30 min by carboxylation of α-lithiomethylisocyanide with a radiochemical yield of 10–15%. After coupling with L -phenylalanine-N-carboxyanhydride and L -leucine-N-carboxyanhydride followed by HPLC purification, the corresponding dipeptides were obtained in 20 min with a radiochemical yield of 30–40%. Consequently, starting with 11 CO 2 , non carrier added L -phenylalanyl[1- 11 C]glycine and L -leucyl[1- 11 C]glycine in 0.1 N NaH 2 PO 4 were obtained in 50 min with a radiochemical yield of 3–6%. The radiochemical yield figures are not corrected for decay.
- Subjects :
- Carbon Isotopes
Dipeptide
Stereochemistry
General Engineering
Glycine
chemistry.chemical_element
Dipeptides
L-phenylalanylglycine
High-performance liquid chromatography
chemistry.chemical_compound
chemistry
Carboxylation
Yield (chemistry)
Isotope Labeling
Leucylglycine
Indicators and Reagents
Carbon
Nuclear chemistry
Subjects
Details
- ISSN :
- 08832889
- Volume :
- 37
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes
- Accession number :
- edsair.doi.dedup.....73188e7e09cdd3d1b862787f08c06bd4