Back to Search
Start Over
Favorable Prognosis of Wheat Allergy in Adults
- Source :
- Journal of investigational allergologyclinical immunology. 29(2)
- Publication Year :
- 2019
-
Abstract
- Background and objective Wheat ingestion can lead to disorders such as IgE-mediated food allergy and wheat-dependent exercise-induced anaphylaxis (WDEIA), both of which are associated with impaired quality of life and significant morbidity. Allergy to wheat is relatively benign in children, although its natural history in adults is still unknown. Objective: We used placebo-controlled challenge to evaluate the natural history of wheat hypersensitivity in atopic patients with adultonset wheat allergy. Methods We enrolled 13 patients from an initial cohort of adult patients with IgE-mediated wheat allergy (mean age, 40 years). After diagnosis, the patients observed a wheat-free diet and were followed as outpatients for 5 years to evaluate wheat exposure. Wheat-IgEtiters were determined at the end of follow-up, and a second wheat-challenge was performed. Results Ten out of 13 patients took part in the study. The mean period of wheat avoidance was 4.2 years. Three patients had spontaneously reintroduced wheat before the second evaluation, after a mean (IQR) of 28 (18-36) months, with only mild gastrointestinal discomfort at reintroduction. At the end of follow-up, 9 of the 10 patients were wheat-tolerant. Two patients had a history of WDEIA. We observed a reduction in IgE levels, with median (IQR) IgE falling from 2.77 (0.35-100) kU/L at diagnosis to 0.88 (0.1-20.8) kU/L. The association between IgE and a negative challenge result was not statistically significant. Conclusion IgE-mediated wheat allergy in adults is benign and represents a temporary break in gastrointestinal tolerance. Future studies may improve our knowledge of wheat allergens, routes of and factors leading to sensitization, and prognostic biomarkers.
- Subjects :
- Adult
Male
Allergy
medicine.medical_specialty
Adolescent
Immunology
Wheat Hypersensitivity
Cross Reactions
01 natural sciences
03 medical and health sciences
Young Adult
0302 clinical medicine
Quality of life
Food allergy
Internal medicine
medicine
Immunology and Allergy
Ingestion
Humans
Triticum
Skin Tests
business.industry
010401 analytical chemistry
food and beverages
Allergens
Immunoglobulin E
Middle Aged
medicine.disease
Prognosis
0104 chemical sciences
Natural history
Patient Outcome Assessment
030228 respiratory system
Cohort
Female
business
Anaphylaxis
Wheat allergy
Follow-Up Studies
Subjects
Details
- ISSN :
- 10189068
- Volume :
- 29
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal of investigational allergologyclinical immunology
- Accession number :
- edsair.doi.dedup.....732632986bfb6d66e6038d49a22fc093