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New models for cancer research: Human cancer stem cell xenografts
- Publication Year :
- 2010
-
Abstract
- Human cancer stem cells represent promising tools for new approaches to pathway-targeted drug discovery and preclinical screening. Because of their distinctive capability to recapitulate the development of the original tumors in vivo, the study of human cancer stem cells (CSCs) largely relies on models of xenograft transplantation into immunodeficient mice. In this frame, immunity and microenvironment-related issues need careful consideration. Here we shortly revise present knowledge on xenograft-related aspects of human CSCs studies.
- Subjects :
- Neoplasm Transplantation
Antineoplastic Agents
Mice, SCID
Biology
SCID
Cell Line
Mice
Experimental
Immunity
In vivo
Settore MED/04 - PATOLOGIA GENERALE
Cell Line, Tumor
Neoplasms
Drug Discovery
Animals
Humans
Pharmacology
Tumor
Drug discovery
Drug Discovery3003 Pharmaceutical Science
Neoplasms, Experimental
Neoplastic Stem Cells
Xenograft Model Antitumor Assays
Cell culture
Cancer research
Experimental pathology
Stem cell
Human cancer
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....7348cc276737bd53d4123cfed09dc6d2