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The Mitochondrion: A Promising Target for Kidney Disease

Authors :
Cem Tanriover
Sidar Copur
Duygu Ucku
Ahmet B. Cakir
Nuri B. Hasbal
Maria Jose Soler
Mehmet Kanbay
Institut Català de la Salut
[Tanriover C, Copur S, Ucku D, Cakir AB] Department of Medicine, Koc University School of Medicine, Istanbul, Turkey. [Hasbal NB, Kanbay M] Department of Medicine, Division of Nephrology, Koc University School of Medicine, Istanbul, Turkey. [Soler MJ] Grup de Recerca de Nefrologia i Trasplantament Renal, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain
Vall d'Hebron Barcelona Hospital Campus
Source :
Scientia
Publication Year :
2023
Publisher :
MDPI AG, 2023.

Abstract

Acute kidney injury; Chronic kidney disease; Mitochondrial dysfunction Lesión renal aguda; Enfermedad renal crónica; Disfunción mitocondrial Lesió renal aguda; Malaltia renal crònica; Disfunció mitocondrial Mitochondrial dysfunction is important in the pathogenesis of various kidney diseases and the mitochondria potentially serve as therapeutic targets necessitating further investigation. Alterations in mitochondrial biogenesis, imbalance between fusion and fission processes leading to mitochondrial fragmentation, oxidative stress, release of cytochrome c and mitochondrial DNA resulting in apoptosis, mitophagy, and defects in energy metabolism are the key pathophysiological mechanisms underlying the role of mitochondrial dysfunction in kidney diseases. Currently, various strategies target the mitochondria to improve kidney function and kidney treatment. The agents used in these strategies can be classified as biogenesis activators, fission inhibitors, antioxidants, mPTP inhibitors, and agents which enhance mitophagy and cardiolipin-protective drugs. Several glucose-lowering drugs, such as glucagon-like peptide-1 receptor agonists (GLP-1-RA) and sodium glucose co-transporter-2 (SGLT-2) inhibitors are also known to have influences on these mechanisms. In this review, we delineate the role of mitochondrial dysfunction in kidney disease, the current mitochondria-targeting treatment options affecting the kidneys and the future role of mitochondria in kidney pathology.

Details

ISSN :
19994923
Volume :
15
Database :
OpenAIRE
Journal :
Pharmaceutics
Accession number :
edsair.doi.dedup.....734ccfff48b6edbf7648c08da42cf211
Full Text :
https://doi.org/10.3390/pharmaceutics15020570