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Implementation of material decomposition using an EMCCD and CMOS-based micro-CT system

Authors :
Daniel R. Bednarek
Swetadri Vasan Setlur Nagesh
Ciprian N. Ionita
Stephen Rudin
Alexander R. Podgorsak
Source :
Medical Imaging: Biomedical Applications in Molecular, Structural, and Functional Imaging
Publication Year :
2017
Publisher :
SPIE, 2017.

Abstract

This project assessed the effectiveness of using two different detectors to obtain dual-energy (DE) micro-CT data for the carrying out of material decomposition. A micro-CT coupled to either a complementary metal-oxide semiconductor (CMOS) or an electron multiplying CCD (EMCCD) detector was used to acquire image data of a 3D-printed phantom with channels filled with different materials. At any instance, materials such as iohexol contrast agent, water, and platinum were selected to make up the scanned object. DE micro-CT data was acquired, and slices of the scanned object were differentiated by material makeup. The success of the decomposition was assessed quantitatively through the computation of percentage normalized root-mean-square error (%NRMSE). Our results indicate a successful decomposition of iohexol for both detectors (%NRMSE values of 1.8 for EMCCD, 2.4 for CMOS), as well as platinum (%NRMSE value of 4.7). The CMOS detector performed material decomposition on air and water on average with 7 times more %NRMSE, possibly due to the decreased sensitivity of the CMOS system. Material decomposition showed the potential to differentiate between materials such as the iohexol and platinum, perhaps opening the door for its use in the neurovascular anatomical region. Work supported by Toshiba America Medical Systems, and partially supported by NIH grant 2R01EB002873.

Details

ISSN :
0277786X
Database :
OpenAIRE
Journal :
Medical Imaging 2017: Biomedical Applications in Molecular, Structural, and Functional Imaging
Accession number :
edsair.doi.dedup.....73642409cc6902fd5bdccbd2008f33ce
Full Text :
https://doi.org/10.1117/12.2253892