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Leukocyte telomere length, T cell composition and DNA methylation age
- Source :
- Aging (Albany NY)
- Publication Year :
- 2017
- Publisher :
- Impact Journals, LLC, 2017.
-
Abstract
- Both leukocyte telomere length (LTL) and DNA methylation age are strongly associated with chronological age. One measure of DNA methylation age─ the extrinsic epigenetic age acceleration (EEAA)─ is highly predictive of all-cause mortality. We examined the relation between LTL and EEAA. LTL was measured by Southern blots and leukocyte DNA methylation was determined using Illumina Infinium HumanMethylation450 BeadChip in participants in the Women's Health Initiative (WHI; n=804), the Framingham Heart Study (FHS; n=909) and the Bogalusa Heart study (BHS; n=826). EEAA was computed using 71 DNA methylation sites, further weighted by proportions of naive CD8+ T cells, memory CD8+ T cells, and plasmablasts. Shorter LTL was associated with increased EEAA in participants from the WHI (r=-0.16, p=3.1x10-6). This finding was replicated in the FHS (r=-0.09, p=6.5x10-3) and the BHS (r=-0.07, p=3.8x 10-2). LTL was also inversely related to proportions of memory CD8+ T cells (p=4.04x10-16) and positively related to proportions of naive CD8+ T cells (p=3.57x10-14). These findings suggest that for a given age, an individual whose blood contains comparatively more memory CD8+ T cells and less naive CD8+ T cells would display a relatively shorter LTL and an older DNA methylation age, which jointly explain the striking ability of EEAA to predict mortality.
- Subjects :
- Adult
Male
0301 basic medicine
Aging
medicine.medical_specialty
T cell
T cells
naïve
CD8-Positive T-Lymphocytes
Biology
memory
03 medical and health sciences
0302 clinical medicine
Framingham Heart Study
Internal medicine
Leukocytes
medicine
Humans
Epigenetics
Aged
Southern blot
DNA methylation
Cell Biology
Chronological age
Middle Aged
Telomere
telomeres
3. Good health
030104 developmental biology
Endocrinology
medicine.anatomical_structure
Female
030217 neurology & neurosurgery
CD8
Research Paper
Subjects
Details
- ISSN :
- 19454589
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Aging
- Accession number :
- edsair.doi.dedup.....736cae04304b85c290975ffa2d95b578