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Different Expressions of AQP1 and AQP4 in Hyponatremic Rat Brain
- Source :
- International Journal of Morphology v.39 n.1 2021, SciELO Chile, CONICYT Chile, instacron:CONICYT
- Publication Year :
- 2021
- Publisher :
- SciELO Agencia Nacional de Investigacion y Desarrollo (ANID), 2021.
-
Abstract
- SUMMARY: The expression of aquaporin-1 (AQP1) in choroid plexus and aquaporin-4 (AQP4) in astrocyte of the hippocampal formation (HF) was studied in the rat to determine the role of AQP1 and AQP4 in the pathophysiology of systemic hyponatremia (SH). SH was induced by coadministration of dextrose solution intraperitoneally and through subcutaneous implantation of an osmotic minipump containing 8-deamino-arginin vasopressin (50ng/µl/h) for 24 and 48 h. Twenty- four and 48 h after the drug administration, there were significant reductions in Na+ concentration (111 ± 5 and 104 ± 2 mmol) and serum osmolarity (240 ± 13 and 221 ± 14 mOsm/L) as compared with control values (140 ± 4.7 mmol and 296 ± 5.2 mOsm/L), (p
- Subjects :
- Aquaporin-1
Cell death
Systemic hyponatremia
Chemistry
Anatomy
Aquaporin-4
Subjects
Details
- ISSN :
- 07179502
- Volume :
- 39
- Database :
- OpenAIRE
- Journal :
- International Journal of Morphology
- Accession number :
- edsair.doi.dedup.....73891563a121d9f88c3da1663c3a40ad