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Shigella sonnei Encodes a Functional T6SS Used for Interbacterial Competition and Niche Occupancy
- Source :
- Cell hostmicrobe. 21(6)
- Publication Year :
- 2017
-
Abstract
- Shigella is a leading cause of dysentery worldwide, with the majority of infections caused by two subgroups, S. flexneri and S. sonnei. Although S. flexneri has been highly prevalent in low-income countries, global development has brought an increase in S. sonnei at the expense of S. flexneri. However, the mechanisms behind this shift are not understood. Here we report that S. sonnei, but not S. flexneri, encodes a type VI secretion system (T6SS) that provides a competitive advantage in the gut. S. sonnei competes against E. coli and S. flexneri in mixed cultures, but this advantage is reduced in T6SS mutant strains. In addition, S. sonnei can persist as well as outcompete E. coli and S. flexneri in mice in a T6SS-dependent manner. These findings suggest that S. sonnei has a competitive advantage over S. flexneri and potentially explain the increasing global prevalence of S. sonnei.
- Subjects :
- 0301 basic medicine
Colon
media_common.quotation_subject
030106 microbiology
Mutant
Niche
Guinea Pigs
Colony Count, Microbial
Shigella sonnei
Biology
medicine.disease_cause
Microbiology
Competitive advantage
Competition (biology)
Shigella flexneri
03 medical and health sciences
Mice
fluids and secretions
Virology
Antibiosis
medicine
Escherichia coli
Animals
Shigella
Secretion
media_common
Dysentery, Bacillary
Mice, Inbred BALB C
Dysentery
biochemical phenomena, metabolism, and nutrition
Type VI Secretion Systems
bacterial infections and mycoses
medicine.disease
digestive system diseases
Coculture Techniques
3. Good health
Disease Models, Animal
Lactobacillus
030104 developmental biology
Mutation
bacteria
Microbial Interactions
Parasitology
Female
Subjects
Details
- ISSN :
- 19346069
- Volume :
- 21
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Cell hostmicrobe
- Accession number :
- edsair.doi.dedup.....73bb373883e8197fb2d5750f973bd4eb