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Insulin-related metabolism following hematopoietic stem cell transplantation in childhood
- Source :
- Pediatric Diabetes. 10:149-154
- Publication Year :
- 2009
- Publisher :
- Hindawi Limited, 2009.
-
Abstract
- Objectives: To assess insulin-related metabolism following hematopoietic stem cell transplantation (HSCT) in childhood. Study design: Thirty-four patients who underwent HSCT were compared with 21 patients with similar diseases who were not transplanted. Median follow-up was 3.6 yr after HSCT. Anthropometric parameters, fasting plasma glucose and insulin levels, hemoglobin A1c (HbA1c) and lipid profile were measured and compared. Results: HbA1c was significantly higher (p = 0.001) in the study group. Two (5.8%) patients in the study group developed type 2 diabetes mellitus. Among thalassemic patients, significantly lower insulin resistance indices (p = 0.05) and fasting plasma insulin levels (p = 0.033) were found in the study group compared with the control group. Conclusions: Attentive follow-up of insulin-related metabolism following HSCT in children is needed. The significance of the higher HbA1c values in the study group remains to be evaluated in a larger cohort of patients.
- Subjects :
- Blood Glucose
Male
medicine.medical_specialty
Transplantation Conditioning
Adolescent
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Thalassemia
Hematopoietic stem cell transplantation
Transplantation, Autologous
Gastroenterology
Young Adult
Insulin resistance
Internal medicine
Internal Medicine
Humans
Insulin
Transplantation, Homologous
Medicine
Child
Glycated Hemoglobin
medicine.diagnostic_test
business.industry
Hematopoietic Stem Cell Transplantation
Type 2 Diabetes Mellitus
Lipid Metabolism
medicine.disease
Transplantation
Endocrinology
Child, Preschool
Pediatrics, Perinatology and Child Health
Cohort
Female
Insulin Resistance
business
Lipid profile
Follow-Up Studies
Subjects
Details
- ISSN :
- 13995448 and 1399543X
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Pediatric Diabetes
- Accession number :
- edsair.doi.dedup.....73d9886809647c7f6d0fbae1a41d1f60