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Glutamatergic receptor expression changes in the Alzheimer's disease hippocampus and entorhinal cortex
- Source :
- Brain Pathology
- Publication Year :
- 2021
-
Abstract
- Alzheimer's Disease (AD) is the leading form of dementia worldwide. Currently, the pathological mechanisms underlying AD are not well understood. Although the glutamatergic system is extensively implicated in its pathophysiology, there is a gap in knowledge regarding the expression of glutamate receptors in the AD brain. This study aimed to characterize the expression of specific glutamate receptor subunits in post‐mortem human brain tissue using immunohistochemistry and confocal microscopy. Free‐floating immunohistochemistry and confocal laser scanning microscopy were used to quantify the density of glutamate receptor subunits GluA2, GluN1, and GluN2A in specific cell layers of the hippocampal sub‐regions, subiculum, entorhinal cortex, and superior temporal gyrus. Quantification of GluA2 expression in human post‐mortem hippocampus revealed a significant increase in the stratum (str.) moleculare of the dentate gyrus (DG) in AD compared with control. Increased GluN1 receptor expression was found in the str. moleculare and hilus of the DG, str. oriens of the CA2 and CA3, str. pyramidale of the CA2, and str. radiatum of the CA1, CA2, and CA3 subregions and the entorhinal cortex. GluN2A expression was significantly increased in AD compared with control in the str. oriens, str. pyramidale, and str. radiatum of the CA1 subregion. These findings indicate that the expression of glutamatergic receptor subunits shows brain region‐specific changes in AD, suggesting possible pathological receptor functioning. These results provide evidence of specific glutamatergic receptor subunit changes in the AD hippocampus and entorhinal cortex, indicating the requirement for further research to elucidate the pathophysiological mechanisms it entails, and further highlight the potential of glutamatergic receptor subunits as therapeutic targets.<br />GTC Glutamatergic receptor GluA2, GluN1, and GluN2A subunit expression changes in the Alzheimer's disease hippocampus and entorhinal cortex.
- Subjects :
- Male
glutamate receptor
hippocampus
Receptor expression
Hippocampus
Hippocampal formation
Biology
Pathology and Forensic Medicine
Glutamatergic
Alzheimer Disease
medicine
Humans
Research Articles
Aged
Aged, 80 and over
Neurons
entorhinal cortex
General Neuroscience
Dentate gyrus
Subiculum
Human brain
Middle Aged
Alzheimer's disease
Entorhinal cortex
NMDA receptor
medicine.anatomical_structure
nervous system
Receptors, Glutamate
superior temporal gyrus
subiculum
Female
Neurology (clinical)
Neuroscience
Research Article
AMAPA receptor
Subjects
Details
- ISSN :
- 17503639
- Volume :
- 31
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Brain pathology (Zurich, Switzerland)
- Accession number :
- edsair.doi.dedup.....73eddc94ab87832be1408de324b3572e