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Neuropsychological, neuropsychiatric, and quality‐of‐life assessments in Alzheimer's disease patients treated with plasma exchange with albumin replacement from the randomized AMBAR study
- Source :
- Alzheimer's & Dementia. 18:1314-1324
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Introduction We report the effects of plasma exchange (PE) with albumin replacement on neuropsychological, neuropsychiatric, and quality-of-life (QoL) outcomes in mild-to-moderate Alzheimer's disease (AD) patients in a phase 2b/3 trial (Alzheimer's Management by Albumin Replacement [AMBAR] study). Methods Three hundred forty-seven patients were randomized into placebo (sham-PE) and three PE-treatment arms with low/high doses of albumin, with/without intravenous immunoglobulin (IVIG). Specific test measurements were performed at baseline; month 2 (weekly conventional PE); months 6, 9, and 12 (monthly low-volume PE [LVPE]); and month 14. Results The PE-treated mild-AD cohort improved their language fluency and processing speed versus placebo at month 14 (effect sizes: >100%; P-values: .03 to .001). The moderate-AD cohort significantly improved short-term verbal memory (effect sizes: 94% to >100%; P-values: .02 to .003). The progression of the neuropsychiatric symptoms of PE-treated was similar to placebo. Mild-AD patients showed improved QoL (P-values: .04 to .008). Discussion PE-treated AD patients showed improvement in memory, language abilities, processing speed, and QoL-AD. No worsening of their psychoaffective status was observed.
- Subjects :
- medicine.medical_specialty
Epidemiology
medicine.medical_treatment
Neuropsychological Tests
Placebo
Cellular and Molecular Neuroscience
Developmental Neuroscience
Quality of life
Alzheimer Disease
Albumins
Internal medicine
Humans
Medicine
Plasma Exchange
business.industry
Health Policy
Neuropsychology
Albumin
Clinical trial
Psychiatry and Mental health
Cohort
Quality of Life
Methacrylates
Plasmapheresis
Neurology (clinical)
Geriatrics and Gerontology
Verbal memory
business
Subjects
Details
- ISSN :
- 15525279 and 15525260
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Alzheimer's & Dementia
- Accession number :
- edsair.doi.dedup.....73fce711579627bd3786cf07b51554c0