Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis

Authors :: John H. J. Wokke
Cisca Wijmenga
Anna Birve
Jan H. Veldink
Vianney de Jong
Michael A. van Es
Robin Lemmens
Paul W.J. van Vught
Leonard H. van den Berg
Christine Van Broeckhoven
Peter M. Andersen
Bryan J. Traynor
Kristel Sleegers
Ruben van 't Slot
Ludo Van Den Bosch
Frank Baas
Wim Robberecht
Lude Franke
Jennifer C. Schymick
Roel A. Ophoff
Christiaan G J Saris
Helenius J. Schelhaas
Sonja W. de Jong
Hylke M. Blauw
ANS - Amsterdam Neuroscience
Neurology
Genome Analysis
Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI)
Stem Cell Aging Leukemia and Lymphoma (SALL)
Source :: Nature genetics, 40(1), 29-31. Nature Publishing Group, Nature Genetics, 40, 29-31, Nature Genetics, 40, 1, pp. 29-31, Nature genetics, Nature Genetics, 40(1), 29-31. Nature Publishing Group
Publication Year :: 2008
Publisher :: Nature Publishing Group, 2008.
Abstract: Contains fulltext : 70185.pdf (Publisher’s version ) (Closed access) We identified a SNP in the DPP6 gene that is consistently strongly associated with susceptibility to amyotrophic lateral sclerosis (ALS) in different populations of European ancestry, with an overall P value of 5.04 x 10(-8) in 1,767 cases and 1,916 healthy controls and with an odds ratio of 1.30 (95% confidence interval (CI) of 1.18-1.43). Our finding is the first report of a genome-wide significant association with sporadic ALS and may be a target for future functional studies.

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