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Preventing mood and anxiety disorders in youth: a multi-centre RCT in the high risk offspring of depressed and anxious patients
- Source :
- BMC Psychiatry, BMC Psychiatry, 12:31. BMC, BMC Psychiatry, 12, BMC Psychiatry, Vol 12, Iss 1, p 31 (2012), Nauta, M H, Festen, H, Reichart, C G, Nolen, W A, Stant, A D, Bockting, C L H, van der Wee, N J A, Beekman, A T F, Doreleijers, T A H, Hartman, C A, de Jong, P J & de Vries, S O 2012, ' Preventing mood and anxiety disorders in youth: a multi-centre RCT in the high risk offspring of depressed and anxious patients ', BMC Psychiatry, vol. 12, 31 . https://doi.org/10.1186/1471-244X-12-31, BMC PSYCHIATRY, BMC psychiatry, 12. BioMed Central, BMC Psychiatry, 12:31. BioMed Central
- Publication Year :
- 2012
-
Abstract
- Background Anxiety and mood disorders are highly prevalent and pose a huge burden on patients. Their offspring is at increased risk of developing these disorders as well, indicating a clear need for prevention of psychopathology in this group. Given high comorbidity and non-specificity of intergenerational transmission of disorders, prevention programs should target both anxiety and depression. Further, while the indication for preventive interventions is often elevated symptoms, offspring with other high risk profiles may also benefit from resilience-based prevention programs. Method/design The current STERK-study (Screening and Training: Enhancing Resilience in Kids) is a randomized controlled clinical trial combining selected and indicated prevention: it is targeted at both high risk individuals without symptoms and at those with subsyndromal symptoms. Individuals without symptoms meet two of three criteria of the High Risk Index (HRI; female gender, both parents affected, history of a parental suicide (attempt). This index was developed in an earlier study and corresponds with elevated risk in offspring of depressed patients. Children aged 8–17 years (n = 204) with subthreshold symptoms or meeting the criteria on the HRI are randomised to one of two treatment conditions, namely (a) 10 weekly individual child CBT sessions and 2 parent sessions or (b) minimal information. Assessments are held at pre-test, post-test and at 12 and 24 months follow-up. Primary outcome is the time to onset of a mood or anxiety disorder in the offspring. Secondary outcome measures include number of days with depression or anxiety, child and parent symptom levels, quality of life, and cost-effectiveness. Based on models of aetiology of mood and anxiety disorders as well as mechanisms of change during interventions, we selected potential mediators and moderators of treatment outcome, namely coping, parent–child interaction, self-associations, optimism/pessimism, temperament, and emotion processing. Discussion The current intervention trial aims to significantly reduce the risk of intergenerational transmission of mood and anxiety disorders with a short and well targeted intervention that is directed at strengthening the resilience in potentially vulnerable children. We plan to evaluate the effectiveness and cost-effectiveness of such an intervention and to identify mechanisms of change. Trial registration NTR2888
- Subjects :
- DISC-IV
Male
Anxiety/prevention & control
medicine.medical_treatment
Poison control
Social Sciences
Anxiety
COST-EFFECTIVENESS
Study Protocol
Child of Impaired Parents
PARENTS
Risk Factors
lcsh:Psychiatry
Adaptation, Psychological
ADOLESCENTS
Parent-Child Relations
Child
Randomised controlled trial
Depression
RANDOMIZED CONTROLLED-TRIAL
Anxiety Disorders
Cognitive behavioral therapy
Psychiatry and Mental health
Treatment Outcome
Female
medicine.symptom
Psychology
Anxiety Disorders/prevention & control
INTERVENTION
Clinical psychology
Psychopathology
medicine.medical_specialty
Adolescent
Offspring
lcsh:RC435-571
Cost effectiveness
Sex Factors
MENTAL-DISORDERS
medicine
Humans
Adaptation
Psychiatry
Mood Disorders/prevention & control
DIAGNOSTIC INTERVIEW SCHEDULE
Cognitive Behavioral Therapy
Mood Disorders
Prevention
MAJOR DEPRESSION
medicine.disease
Comorbidity
Mood
Mood disorders
Child of Impaired Parents/psychology
Depression/prevention & control
Psychological
CHILD ANXIETY
Subjects
Details
- Language :
- English
- ISSN :
- 1471244X
- Database :
- OpenAIRE
- Journal :
- BMC Psychiatry, BMC Psychiatry, 12:31. BMC, BMC Psychiatry, 12, BMC Psychiatry, Vol 12, Iss 1, p 31 (2012), Nauta, M H, Festen, H, Reichart, C G, Nolen, W A, Stant, A D, Bockting, C L H, van der Wee, N J A, Beekman, A T F, Doreleijers, T A H, Hartman, C A, de Jong, P J & de Vries, S O 2012, ' Preventing mood and anxiety disorders in youth: a multi-centre RCT in the high risk offspring of depressed and anxious patients ', BMC Psychiatry, vol. 12, 31 . https://doi.org/10.1186/1471-244X-12-31, BMC PSYCHIATRY, BMC psychiatry, 12. BioMed Central, BMC Psychiatry, 12:31. BioMed Central
- Accession number :
- edsair.doi.dedup.....741348a550da31a7afaad7246d11708c