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A peek into Epac physiology in the kidney
- Source :
- Am J Physiol Renal Physiol
- Publication Year :
- 2019
- Publisher :
- American Physiological Society, 2019.
-
Abstract
- cAMP is a critical second messenger of numerous endocrine signals affecting water-electrolyte transport in the renal tubule. Exchange protein directly activated by cAMP (Epac) is a relatively recently discovered downstream effector of cAMP, having the same affinity to the second messenger as protein kinase A, the classical cAMP target. Two Epac isoforms, Epac1 and Epac2, are abundantly expressed in the renal epithelium, where they are thought to regulate water and electrolyte transport, particularly in the proximal tubule and collecting duct. Recent characterization of renal phenotype in mice lacking Epac1 and Epac2 revealed a critical role of the Epac signaling cascade in urinary concentration as well as in Na+ and urea excretion. In this review, we aim to critically summarize current knowledge of Epac relevance for renal function and to discuss the applicability of Epac-based strategies in the regulation of systemic water-electrolyte homeostasis.
- Subjects :
- Kidney
medicine.medical_specialty
Renal tubule
Physiology
Chemistry
Review
medicine.anatomical_structure
Endocrinology
Gene Expression Regulation
Renal transport
Internal medicine
Second messenger system
Cyclic AMP
medicine
Animals
Guanine Nucleotide Exchange Factors
Humans
Protein Isoforms
Endocrine system
Proximal tubule
Subjects
Details
- ISSN :
- 15221466 and 1931857X
- Volume :
- 317
- Database :
- OpenAIRE
- Journal :
- American Journal of Physiology-Renal Physiology
- Accession number :
- edsair.doi.dedup.....7425b392cfa6be407386dec1e4f7c2fb