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A prospective study to evaluate the efficacy and safety of oral acetyl-L-carnitine for the treatment of chemotherapy-induced peripheral neuropathy
- Source :
- Experimental and Therapeutic Medicine. 12:4017-4024
- Publication Year :
- 2016
- Publisher :
- Spandidos Publications, 2016.
-
Abstract
- The present study aimed to evaluate the efficacy and safety of acetyl-L-carnitine (ALC) for the treatment of chemotherapy-induced peripheral neuropathy (CIPN). The study was carried out as a prospective, randomized, double-blind, placebo-controlled and paralleled clinical study. A total of 239 patients with CIPN were selected as the study subjects. Of the 239 subjects, 118 subjects received 3 g/day ALC orally for 8 weeks and 121 received a placebo. The primary endpoint was improvement of peripheral neuropathy by at least one grade. Patient status was assessed at week 4, 8 and 12 after enrollment into the study. In both the full analysis set (FAS) and the per-protocol set (PPS), peripheral sensory neuropathy was significantly ameliorated in the ALC group with 50.5 and 51.6% patients meeting the primary endpoint at week 8, compared with 24.1 and 23.1% of patients in the placebo group (P
- Subjects :
- Cancer Research
medicine.medical_specialty
Chemotherapy
business.industry
medicine.medical_treatment
Articles
General Medicine
Pharmacology
Placebo
medicine.disease
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Peripheral neuropathy
Immunology and Microbiology (miscellaneous)
Chemotherapy-induced peripheral neuropathy
Oral administration
030220 oncology & carcinogenesis
Internal medicine
medicine
Clinical endpoint
Adverse effect
business
Prospective cohort study
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 17921015 and 17920981
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Experimental and Therapeutic Medicine
- Accession number :
- edsair.doi.dedup.....74356dc03d1723c9a4690e8e3ce34a53