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Clarithromycin resistance and 23S rRNA gene point mutations of Helicobacter pylori infection in children
- Source :
- The Turkish journal of pediatrics. 58(4)
- Publication Year :
- 2017
-
Abstract
- This study aims to evaluate Helicobacter pylori with clarithromycin resistant genotypes in Manisa region, Turkey. Two hundred patients, who received diagnosis of Helicobacter pylori infection histopathologically, were included. The sex, age and endoscopy indications of the patients were recorded. Polymerase chain reaction method was applied to determine the clarithromycin resistance rate and resistance genotypes at the histologic sections prepared from gastric biopsies that had been embedded in paraffin after fixation by formalin. Helicobacter pylori resistance to clarithromycin was found in 19/200 (9.5%) patients. 10/19 (52.6%) of these clarithromycin-resistant patients had A2143G mutation and 9/19 (47.4%) had A2142G mutation. A2142C mutation on 23S rRNA gene was not detected for any of the patients. Clarithromycin can be used as a first step treatment in the eradication of Helicobacter pylori for the children in our region; if the treatment fails for some patients, clarithromycin resistance, especially A2143G and A2142G mutations should be considered.
- Subjects :
- 0301 basic medicine
Male
medicine.medical_specialty
Adolescent
Genotype
Turkey
Biopsy
030106 microbiology
medicine.disease_cause
Gastroenterology
Polymerase Chain Reaction
law.invention
Helicobacter Infections
03 medical and health sciences
0302 clinical medicine
law
23S ribosomal RNA
Internal medicine
Clarithromycin
Drug Resistance, Bacterial
medicine
Humans
Point Mutation
Child
Gene
Polymerase chain reaction
Mutation
biology
Helicobacter pylori
business.industry
Point mutation
bacterial infections and mycoses
biology.organism_classification
Anti-Bacterial Agents
Child, Preschool
Pediatrics, Perinatology and Child Health
030211 gastroenterology & hepatology
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 27916421
- Volume :
- 58
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- The Turkish journal of pediatrics
- Accession number :
- edsair.doi.dedup.....743df8e6daa401150ab64cf62b3897e6