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Protein kinase CK2 enables regulatory T cells to suppress excessive TH2 responses in vivo
- Source :
- Nature Immunology. 16:267-275
- Publication Year :
- 2015
- Publisher :
- Springer Science and Business Media LLC, 2015.
-
Abstract
- The quality of the adaptive immune response depends on the differentiation of distinct CD4(+) helper T cell subsets, and the magnitude of an immune response is controlled by CD4(+)Foxp3(+) regulatory T cells (Treg cells). However, how a tissue- and cell type-specific suppressor program of Treg cells is mechanistically orchestrated has remained largely unexplored. Through the use of Treg cell-specific gene targeting, we found that the suppression of allergic immune responses in the lungs mediated by T helper type 2 (TH2) cells was dependent on the activity of the protein kinase CK2. Genetic ablation of the β-subunit of CK2 specifically in Treg cells resulted in the proliferation of a hitherto-unexplored ILT3(+) Treg cell subpopulation that was unable to control the maturation of IRF4(+)PD-L2(+) dendritic cells required for the development of TH2 responses in vivo.
- Subjects :
- CD4-Positive T-Lymphocytes
Male
T cell
Immunology
Mice, Transgenic
Receptors, Cell Surface
chemical and pharmacologic phenomena
Cell Growth Processes
T-Lymphocytes, Regulatory
Cell Line
Mice
Th2 Cells
Immune system
Hypersensitivity
medicine
Animals
Humans
Immunology and Allergy
IL-2 receptor
Casein Kinase II
Mice, Inbred BALB C
Chemistry
Peripheral tolerance
FOXP3
Cell Differentiation
Forkhead Transcription Factors
Dendritic Cells
Acquired immune system
Cell biology
Mice, Inbred C57BL
medicine.anatomical_structure
Cell culture
Interferon Regulatory Factors
Leukocytes, Mononuclear
IRF4
Subjects
Details
- ISSN :
- 15292916 and 15292908
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Nature Immunology
- Accession number :
- edsair.doi.dedup.....745a754685d64a3fc15d630c1f5a41cc