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The effect of the apolipoprotein E gene polymorphisms and haplotypes on behavioural and psychological symptoms in probable Alzheimer's disease
The effect of the apolipoprotein E gene polymorphisms and haplotypes on behavioural and psychological symptoms in probable Alzheimer's disease
- Source :
- Journal of Neurology, Neurosurgery & Psychiatry. 78:123-126
- Publication Year :
- 2007
- Publisher :
- BMJ, 2007.
-
Abstract
- Background: Patients with Alzheimer’s disease and dementia commonly suffer from behavioural and psychological symptoms of dementia (BPSD). A genetic component to BPSD development in Alzheimer’s disease has been demonstrated. Several studies have investigated whether the exon 4 e2/e3/e4 haplotype of the apolipoprotein E ( APOE ) gene is associated with BPSD, with variable results. Objective: We investigated the exon 4 polymorphisms and extended this study to include promoter polymorphisms and the resultant haplotypes across the gene. Methods: Our large independent cohort of 388 patients with longitudinal measures of BPSD assessed by the Neuropsychiatric Inventory was used to analyse whether any of these variants were associated with the presence of BPSD. Results: We revealed several significant relationships before correction for multiple testing. The exon 4 haplotype was associated with hallucinations and anxiety, A-491T with irritability, T-427C with agitation/aggression and appetite disturbances, and T-219C with depression. Haplotype analyses of all variants did not reveal any statistically significant findings. Conclusions: Our data and a review of previous studies showed a diversity of relationships, suggesting that these findings might be due to chance and so collectively do not support a role for the APOE gene in BPSD.
- Subjects :
- Male
Paper
Apolipoprotein E
medicine.medical_specialty
Hallucinations
Apolipoprotein E4
Disease
Anxiety
Bioinformatics
Irritability
Exon
Degenerative disease
Alzheimer Disease
medicine
Humans
Dementia
Longitudinal Studies
Psychiatry
Aged
Aged, 80 and over
Polymorphism, Genetic
Depression
Haplotype
Middle Aged
medicine.disease
Aggression
Psychiatry and Mental health
Haplotypes
Female
Surgery
Neurology (clinical)
medicine.symptom
Alzheimer's disease
Psychology
Subjects
Details
- ISSN :
- 00223050
- Volume :
- 78
- Database :
- OpenAIRE
- Journal :
- Journal of Neurology, Neurosurgery & Psychiatry
- Accession number :
- edsair.doi.dedup.....7464e8efafbe121298a2bde3222f5278
- Full Text :
- https://doi.org/10.1136/jnnp.2006.092122