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Impact of Sleep Apnea on Cardioembolic Risk in Patients With Atrial Fibrillation: Data From the ESADA Cohort
- Source :
- Stroke. 52(2)
- Publication Year :
- 2020
-
Abstract
- Background and Purpose: An accurate determination of the cardioembolic risk in patients with atrial fibrillation (AF) is crucial to prevent consequences like stroke. Obstructive sleep apnea (OSA) is a known risk factor for both AF and stroke. We aim to explore a possible association between OSA and an increased cardioembolic risk in patients with AF. Methods: We assessed data from the ESADA (European Sleep Apnea Database) cohort where patients with known AF and OSA were included. Parameters of OSA severity and related hypoxia like lowest Sp o 2 and 4% oxygen desaturation index were analyzed. Patients were stratified according to their cardioembolic risk estimated with the CHA 2 DS 2 -VASc score. Results: From the initial cohort of 14 646 patients, a final set of 363 patients were included in the analysis. Indices of hypoxia during sleep were associated with increased CHA 2 DS 2 -VASc score (4% oxygen desaturation index 17.9 versus 29.6 versus 30.5 events/hour and the lowest Sp o 2 81.2 versus 77.8 versus 77.5% for low, moderate, and high cardioembolic risk, respectively, P Conclusions: These results support the potential role of OSA-related hypoxia in the risk for cardioembolic complications such as stroke in patients with AF.
- Subjects :
- Male
medicine.medical_specialty
Databases, Factual
Heart Diseases
Embolism
030204 cardiovascular system & hematology
Risk Assessment
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Internal medicine
Atrial Fibrillation
medicine
Humans
Risk factor
Hypoxia
Stroke
Aged
Advanced and Specialized Nursing
Aged, 80 and over
Sleep Apnea, Obstructive
business.industry
Sleep apnea
Atrial fibrillation
Hypoxia (medical)
Middle Aged
medicine.disease
atrial fibrillation
embolism
hypoxia
risk factor
sleep apnea
Obstructive sleep apnea
Oxygen
030228 respiratory system
Cohort
Cardiology
Female
Neurology (clinical)
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 15244628
- Volume :
- 52
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Stroke
- Accession number :
- edsair.doi.dedup.....7469494801ccddc0a7293cb64bd441d7