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pH-Sensitive Micelles Based on Star Copolymer Ad-(PCL-b-PDEAEMA-b-PPEGMA)₄ for Controlled Drug Delivery
- Source :
- Polymers; Volume 10; Issue 4; Pages: 443, Polymers, Polymers, Vol 10, Iss 4, p 443 (2018)
- Publication Year :
- 2018
-
Abstract
- Enhancing drug loading efficacy and stability of polymeric micelles remains a grand challenge. Here we develop adamantane-based star copolymers adamantane-[poly(ε-caprolactone)-b-poly(2-(diethylamino)ethyl methacrylate)-b-poly(poly(ethylene glycol) methyl ether methacrylate)]4 (Ad-(PCL-b-PDEAEMA-b-PPEGMA)4) and their self-assembled micelles for controlled drug delivery. Results show that the polymers have excellent stability in solution with low critical micelle concentration (CMC) (0.0025–0.0034 mg/mL) and the apparent base dissociation constant (pKb) of the polymers is from 5.31 to 6.05. Dynamic light scattering analysis exhibits the great environmental response capability of the pH-sensitive micelles according to particle sizes and zeta potentials. With the synergy effect of the adamantane and hydrophobic block, the micelles display the high Doxorubicin (DOX) loading efficacy (up to 22.4%). The DOX release study shows that the micelles are capable of controlled release for drug. This work indicates the Ad-(PCL-b-PDEAEMA-b-PPEGMA)4 micelles may provide new guidelines for drug control and release system in overcoming cancer treatment.
- Subjects :
- Polymers and Plastics
Adamantane
anti-cancer drug delivery
adamantane
02 engineering and technology
star polymer
010402 general chemistry
Methacrylate
01 natural sciences
Micelle
Article
lcsh:QD241-441
chemistry.chemical_compound
polymeric micelles
pH-responsive
lcsh:Organic chemistry
Drug control
General Chemistry
021001 nanoscience & nanotechnology
Controlled release
0104 chemical sciences
chemistry
Chemical engineering
Critical micelle concentration
Drug delivery
0210 nano-technology
Ethylene glycol
Subjects
Details
- ISSN :
- 20734360
- Volume :
- 10
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Polymers
- Accession number :
- edsair.doi.dedup.....746ce8602f86158f7e74926b99c71894