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Improving the Yield of Blood Cultures from Patients with Early Lyme Disease
- Source :
- Journal of Clinical Microbiology. 49:2166-2168
- Publication Year :
- 2011
- Publisher :
- American Society for Microbiology, 2011.
-
Abstract
- Approximately 45% of untreated United States patients with early Lyme disease associated with erythema migrans have a positive blood culture based on microscopic detection of Borrelia burgdorferi in Barbour-Stoenner-Kelly medium after 2 to 12 weeks of incubation. In this study we demonstrate that the yield of blood cultures can be significantly increased to 70.8% by the use of a combined culture-quantitative PCR technique and that among those patients found to have a positive blood culture, positivity was detected in over 90% within just 7 days of incubation. Patients with multiple erythema migrans were almost uniformly culture positive by this technique.
- Subjects :
- Adult
Male
Microbiology (medical)
Polymerase Chain Reaction
Sensitivity and Specificity
Lyme disease
medicine
Humans
Blood culture
Borrelia burgdorferi
Aged
Whole blood
Aged, 80 and over
Bacteriological Techniques
Lyme Disease
biology
medicine.diagnostic_test
business.industry
Bacteriology
Middle Aged
biology.organism_classification
medicine.disease
United States
Blood
Bacteremia
Immunology
Erythema chronicum migrans
Lyme disease microbiology
Erythema migrans
Female
medicine.symptom
business
Subjects
Details
- ISSN :
- 1098660X and 00951137
- Volume :
- 49
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Microbiology
- Accession number :
- edsair.doi.dedup.....747b260b51d11480e4fd83792ae81473