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Infection within 2 weeks before liver transplantation closely related to prognosis of posttransplant infection: A single-center retrospective observational study in China
- Source :
- Hepatobiliary & Pancreatic Diseases International. 19:358-364
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Infections still represent the main factors influencing morbidity and mortality following liver transplantation. This study aimed to evaluate the incidence and risk factors for infection and survival after liver transplantation.We retrospectively examined medical records in 210 liver recipients who underwent liver transplantation between April 2015 and October 2017 in our hospital. Clinical manifestations and results of pathogen detection test were used to define infection. We analyzed the prevalence, risk factors and prognosis of patients with infection.The median follow-up was 214 days; the incidence of infection after liver transplantation was 46.7% (n = 98) which included pneumonia (43.4%), biliary tract infection (21.9%), peritonitis (21.4%) and bloodstream infection (7.6%). Among the pathogens in pneumonia, the most frequently isolated was Acinetobacter baumanii (23.5%) and Klebsiella pneumoniae (21.2%). Model for end-stage liver disease (MELD) score (OR = 1.083, 95% CI: 1.045-1.123; P0.001), biliary complication (OR = 4.725, 95% CI: 1.119-19.947; P = 0.035) and duration of drainage tube (OR = 1.040, 95% CI: 1.007-1.074; P = 0.017) were independent risk factors for posttransplant infection. All-cause mortality was 11.0% (n = 23). The prognostic factors for postoperative infection in liver recipients were prior-transplant infection, especially pneumonia within 2 weeks before transplantation. Kaplan-Meier curves of survival showed that recipients within 2 weeks prior infection had a significantly lower cumulative survival rate compared with those without infection (65.2% vs. 90.0%; hazard ratio: 4.480; P0.001).Infection, especially pneumonia within 2 weeks before transplantation, complication with impaired renal function and MELD score after 7 days of transplantation was an independent prognostic factor for postoperative infection in liver transplant recipients.
- Subjects :
- Adult
Male
China
medicine.medical_specialty
Adolescent
medicine.medical_treatment
Peritonitis
Liver transplantation
Infections
Single Center
End Stage Liver Disease
Young Adult
03 medical and health sciences
Liver disease
0302 clinical medicine
Risk Factors
Internal medicine
Humans
Medicine
Child
Aged
Retrospective Studies
Hepatology
business.industry
Incidence
Incidence (epidemiology)
Gastroenterology
Infant
Retrospective cohort study
Middle Aged
Prognosis
medicine.disease
Liver Transplantation
Transplantation
Pneumonia
Child, Preschool
030220 oncology & carcinogenesis
Female
030211 gastroenterology & hepatology
business
Subjects
Details
- ISSN :
- 14993872
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Hepatobiliary & Pancreatic Diseases International
- Accession number :
- edsair.doi.dedup.....748a0bc1d01617839f718da1d3171502