Effect of medroxyprogesterone acetate on thyrotropin secretion in adult and old female rats

Authors :: Patricia Cristina Lisboa
C. C. Pazos-Moura
P.P. Borges
Egberto Gaspar de Moura
F. H. Curty
R.M. Moreira
Source :: Brazilian Journal of Medical and Biological Research, Vol 33, Iss 9, Pp 1111-1118 (2000), Brazilian Journal of Medical and Biological Research, Volume: 33, Issue: 9, Pages: 1111-1118, Published: SEP 2000, Brazilian Journal of Medical and Biological Research v.33 n.9 2000, Brazilian Journal of Medical and Biological Research, Associação Brasileira de Divulgação Científica (ABDC), instacron:ABDC
Publication Year :: 2000
Publisher :: FapUNIFESP (SciELO), 2000.
Abstract: Steroid hormones have been implicated in the modulation of TSH secretion; however, there are few and controversial data regarding the effect of progesterone (Pg) on TSH secretion. Medroxyprogesterone acetate (MPA) is a synthetic alpha-hydroxyprogesterone analog that has been extensively employed in therapeutics for its Pg-like actions, but that also has some glucocorticoid and androgen activity. Both hormones have been shown to interfere with TSH secretion. The objective of the present study was to investigate the effects of MPA or Pg administration to ovariectomized (OVX) rats on in vivo and in vitro TSH release and pituitary TSH content. The treatment of adult OVX rats with MPA (0.25 mg/100 g body weight, sc, daily for 9 days) induced a significant (P

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