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The high immunogenicity induced by modified sporozoites’ malarial peptides depends on their phi (ϕ) and psi (ψ) angles

Authors :
Martha Patricia Alba
Adriana Bermúdez
Manuel E. Patarroyo
Source :
Repositorio EdocUR-U. Rosario, Universidad del Rosario, instacron:Universidad del Rosario
Publication Year :
2012
Publisher :
Elsevier BV, 2012.

Abstract

The importance of CSP- and STARP-derived ? and ? dihedral angles in mHABP structure was analysed by 1H NMR in the search for molecules which can be included as components of a first-line-of-defence Plasmodium falciparum sporozoite multi-epitope vaccine against the most lethal form of human malaria. Most of the aforementioned dihedral angles were left-hand-like polyproline type II (PPIIL) structures whilst others had right-hand-like ?-helix (?R), thus allowing mHABPS to fit better into MHCII molecules and thereby form an appropriate pMHCII complex and also establish the H-bonds which stabilise such complex and by this means induce an appropriate immune response. This information has great implications for vaccine development, malaria being one of them. © 2012 Elsevier Inc.

Details

ISSN :
0006291X
Volume :
429
Database :
OpenAIRE
Journal :
Biochemical and Biophysical Research Communications
Accession number :
edsair.doi.dedup.....74ca98c67e0f743d5677331b3eae5d07
Full Text :
https://doi.org/10.1016/j.bbrc.2012.10.088