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Long-Term Outcomes of T1 Colorectal Cancer after Endoscopic Resection
- Source :
- Journal of Clinical Medicine, Volume 9, Issue 8, Journal of Clinical Medicine, Vol 9, Iss 2451, p 2451 (2020)
- Publication Year :
- 2020
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2020.
-
Abstract
- Background and Aims: Endoscopic resection (ER) for submucosal invasive colorectal cancer (T1 CRC) can be grouped as curative ER (C-ER) and non-curative ER (NC-ER). Little is known about the long-term outcomes of patients in these two groups. Therefore, we have evaluated the long-term outcomes in endoscopically resected T1 CRC patients in C-ER and NC-ER groups. Methods: We conducted a retrospective study on 220 patients with T1 CRC treated with ER from January 2007 to December 2017. First, we investigated the long-term outcomes (5-year overall survival [OS] and recurrence-free survival [RFS]) in the C-ER group (n = 49). In the NC-ER group (n = 171), we compared long-term outcomes between patients who underwent additional surgical resection (ASR) (n = 117) and those who did not (surveillance-only, n = 54). Results: T1 CRC patients in the C-ER and NC-ER groups had a median follow-up of 44 (interquartile range 32&ndash<br />69) months. There was no risk of tumor recurrence and cancer-related deaths in patients with C-ER. In the NC-ER group, the 5-year OS rates were 75.3% and 92.6% in the surveillance-only and ASR subgroups, respectively. The hazard ratio (HR) for ASR in NC-ER vs. surveillance-only in NC-ER was statistically insignificant. However, RFS rates were significantly different between the ASR (97.2%) and surveillance-only (84.0%) subgroups. Multivariate analysis indicated a submucosal invasion depth (SID) of &gt<br />2500 &micro<br />m and margin positivity to be associated with recurrence. Conclusions: The surveillance-only approach can be considered as an alternative surgical option for T1 CRCs in selected patients undergoing NC-ER.
- Subjects :
- medicine.medical_specialty
Multivariate analysis
Colorectal cancer
overall survival
lcsh:Medicine
colorectal cancer
Gastroenterology
Article
03 medical and health sciences
0302 clinical medicine
endoscopic resection
Interquartile range
Internal medicine
medicine
Long term outcomes
Overall survival
Endoscopic resection
recurrence-free survival
business.industry
Hazard ratio
lcsh:R
Retrospective cohort study
General Medicine
medicine.disease
030220 oncology & carcinogenesis
030211 gastroenterology & hepatology
business
Subjects
Details
- Language :
- English
- ISSN :
- 20770383
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Medicine
- Accession number :
- edsair.doi.dedup.....74e0fc4188be12577f71d194c9c627e3
- Full Text :
- https://doi.org/10.3390/jcm9082451