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Outcome of pituitary hormone deficits after surgical treatment of nonfunctioning pituitary macroadenomas
- Source :
- Endocrine. 73:166-176
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Nonfunctionning pituitary macroadenomas (NFPMA) are benign tumors that cause symptoms of mass effects including hypopituitarism. Their primary treatment is transsphenoidal surgery. We aimed to determine the outcome of pituitary hormone deficits after surgical treatment of NFPMA and to identify factors predicting hormonal recovery. We retrospectively included 246 patients with NFPMA diagnosed and operated in one of the two participating centers. All hormonal axes were evaluated except growth hormone (GH). Postoperative improvement of pituitary endocrine function was considered if at least one hormonal deficit had recovered and a lower total number of deficits was observed 1 year after surgery. 80% (n = 197) of patients had one or more pituitary deficits and 28% had complete anterior hypopituitarism. Besides GH, the gonadotropic and thyrotropic axes were the most commonly affected (68% and 62%, respectively). The number of hypopituitary patients dropped significantly to 61% at 1 year (p
- Subjects :
- Adenoma
Anterior hypopituitarism
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
030209 endocrinology & metabolism
Hypopituitarism
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Endocrinology
Internal medicine
Diabetes mellitus
medicine
Humans
Endocrine system
Pituitary Neoplasms
Retrospective Studies
Transsphenoidal surgery
business.industry
Hyperprolactinaemia
medicine.disease
Pituitary Hormones
Treatment Outcome
030220 oncology & carcinogenesis
Diabetes insipidus
business
Hormone
Subjects
Details
- ISSN :
- 15590100 and 1355008X
- Volume :
- 73
- Database :
- OpenAIRE
- Journal :
- Endocrine
- Accession number :
- edsair.doi.dedup.....74f683f1f13657c6ff162df9057daa70