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ENIGMA and the individual: Predicting factors that affect the brain in 35 countries worldwide
- Source :
- NeuroImage, 145, 389-408, NeuroImage, 145, Pt B, pp. 389-408, Neuroimage, NeuroImage, Thompson, P M, Andreassen, O A, Arias-Vasquez, A, Bearden, C E, Boedhoe, P S, Brouwer, R M, Buckner, R L, Buitelaar, J K, Bulayeva, K B, Cannon, D M, Cohen, R A, Conrod, P, Dale, A M, Deary, I J, Dennis, E L, de Reus, M A, Desrivieres, S, Dima, D, Donohoe, G, Fisher, S E, Fouche, J-P, Francks, C, Frangou, S, Franke, B, Ganjgahi, H, Garavan, H, Glahn, D C, Grabe, H J, Guadalupe, T, Gutman, B A, Hashimoto, R, Hibar, D P, Holland, D, Hoogman, M, Pol, H E H, Hosten, N, Jahanshad, N, Kelly, S, Kochunov, P, Kremen, W S, Lee, P H, Mackey, S, Martin, N G, Mazoyer, B, McDonald, C, Medland, S E, Morey, R A, Nichols, T E, Paus, T, Pausova, Z, Schmaal, L, Schumann, G, Shen, L, Sisodiya, S M, Smit, D J A, Smoller, J W, Stein, D J, Stein, J L, Toro, R, Turner, J A, van den Heuvel, M P, van den Heuvel, O L, van Erp, T G M, van Rooij, D, Veltman, D J, Walter, H, Wang, Y, Wardlaw, J M, Whelan, C D, Wright, M J & Ye, J 2015, ' ENIGMA and the individual: Predicting factors that affect the brain in 35 countries worldwide ', NeuroImage . https://doi.org/10.1016/j.neuroimage.2015.11.057, NeuroImage, 145, 389-408. Academic Press Inc., NeuroImage, Elsevier, 2015, ⟨10.1016/j.neuroimage.2015.11.057⟩, Thompson, P M, Dennis, E L, Gutman, B A, Hibar, D P, Jahanshad, N, Kelly, S, Stein, J L, Whelan, C D, Andreassen, O A, Andreassen, O A, Arias-Vasquez, A, Bearden, C E, Bearden, C E, Bearden, C E, Boedhoe, P S, van den Heuvel, O L, Veltman, D J, Brouwer, R M, de Reus, M A, Pol, H E H, van den Heuvel, M P, Buckner, R L, Buitelaar, J K, Fisher, S E, Francks, C, Franke, B, Hoogman, M, van Rooij, D, Buitelaar, J K, Bulayeva, K B, Cannon, D M, Cannon, D M, McDonald, C, Cohen, R A, Conrod, P J, Dale, A M, Holland, D, Thompson, P M, Deary, I J, Wardlaw, J M, Desrivieres, S, Schumann, G, Dima, D, Dima, D, Frangou, S, Donohoe, G, Fisher, S E, Francks, C, Guadalupe, T, Fouche, J P, Stein, D J, Franke, B, Hoogman, M, Franke, B, Ganjgahi, H, Garavan, H, Glahn, D C, Glahn, D C, Grabe, H J, Grabe, H J, Guadalupe, T, Hashimoto, R, Hosten, N, Kochunov, P, Kremen, W S, Lee, P H, Lee, P H, Lee, P H, Mackey, S, Mazoyer, B, Martin, N G, Medland, S E, Morey, R A, Nichols, T E, Nichols, T E, Paus, T, Paus, T, Paus, T, Pausova, Z, Pausova, Z, Shen, L, Shen, L, Sisodiya, S M, Smit, D J A, Smoller, J W, Stein, D J, Stein, J L, Toro, R, Turner, J A, Boedhoe, P S, Schmaal, L, van den Heuvel, O L, Veltman, D J, Boedhoe, P S, Schmaal, L, van den Heuvel, O L, Veltman, D J, van Erp, T G M, Walter, H, Wang, Y, Wardlaw, J M, Wardlaw, J M, Wright, M J, Ye, J & Ye, J 2017, ' ENIGMA and the individual : Predicting factors that affect the brain in 35 countries worldwide ', NeuroImage, vol. 145, pp. 389-408 . https://doi.org/10.1016/j.neuroimage.2015.11.057, Thompson, P M, Dennis, E L, Gutman, B A, Hibar, D P, Jahanshad, N, Kelly, S, Stein, J L, Whelan, C D, Andreassen, O A, Arias-Vasquez, A, Bearden, C E, Boedhoe, P S, van den Heuvel, O L, Veltman, D J, Brouwer, R M, de Reus, M A, Pol, H E H, van den Heuvel, M P, Buckner, R L, Buitelaar, J K, Fisher, S E, Francks, C, Franke, B, Hoogman, M, van Rooij, D, Bulayeva, K B, Cannon, D M, McDonald, C, Cohen, R A, Conrod, P J, Dale, A M, Holland, D, Deary, I J, Wardlaw, J M, Desrivieres, S, Schumann, G, Dima, D, Dima, D, Frangou, S, Donohoe, G, Guadalupe, T, Fouche, J P, Stein, D J, Ganjgahi, H, Garavan, H, Glahn, D C, Grabe, H J, Hashimoto, R, Hosten, N, Kochunov, P, Kremen, W S, Lee, P H, Mackey, S, Mazoyer, B, Martin, N G, Medland, S E, Morey, R A, Nichols, T E, Paus, T, Pausova, Z, Shen, L, Sisodiya, S M, Smit, D J A, Smoller, J W, Toro, R, Turner, J A, Schmaal, L, van Erp, T G M, Walter, H, Wang, Y, Wright, M J & Ye, J 2017, ' ENIGMA and the individual : Predicting factors that affect the brain in 35 countries worldwide ', NeuroImage, vol. 145, pp. 389-408 . https://doi.org/10.1016/j.neuroimage.2015.11.057, NeuroImage, 145(B), 389. Academic Press Inc., NeuroImage, 2015, ⟨10.1016/j.neuroimage.2015.11.057⟩, Thompson, P M, Andreassen, O A, Arias-Vasquez, A, Bearden, C E, Boedhoe, P S, Brouwer, R M, Buckner, R L, Buitelaar, J K, Bulayeva, K B, Cannon, D M, Cohen, R A, Conrod, P J, Dale, A M, Deary, I J, Dennis, E L, de Reus, M A, Desrivieres, S, Dima, D, Donohoe, G, Fisher, S E, Fouche, J-P, Francks, C, Frangou, S, Franke, B, Ganjgahi, H, Garavan, H, Glahn, D C, Grabe, H J, Guadalupe, T, Gutman, B A, Hashimoto, R, Hibar, D P, Holland, D, Hoogman, M, Pol, H E H, Hosten, N, Jahanshad, N, Kelly, S, Kochunov, P, Kremen, W S, Lee, P H, Mackey, S, Martin, N G, Mazoyer, B, McDonald, C, Medland, S E, Morey, R A, Nichols, T E & Paus, T & Wardlaw, J M 2015, ' ENIGMA and the individual : Predicting factors that affect the brain in 35 countries worldwide ', NeuroImage . https://doi.org/10.1016/j.neuroimage.2015.11.057, Thompson, PM; Andreassen, OA; Arias-Vasquez, A; Bearden, CE; Boedhoe, PS; Brouwer, RM; et al.(2017). ENIGMA and the individual: Predicting factors that affect the brain in 35 countries worldwide. NEUROIMAGE, 145, 389-408. doi: 10.1016/j.neuroimage.2015.11.057. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/55m700sp
- Publication Year :
- 2017
-
Abstract
- Contains fulltext : 165964pub.pdf (Publisher’s version ) (Open Access) In this review, we discuss recent work by the ENIGMA Consortium (http://enigma.ini.usc.edu) – a global alliance of over 500 scientists spread across 200 institutions in 35 countries collectively analyzing brain imaging, clinical, and genetic data. Initially formed to detect genetic influences on brain measures, ENIGMA has grown to over 30 working groups studying 12 major brain diseases by pooling and comparing brain data. In some of the largest neuroimaging studies to date – of schizophrenia and major depression – ENIGMA has found replicable disease effects on the brain that are consistent worldwide, as well as factors that modulate disease effects. In partnership with other consortia including ADNI, CHARGE, IMAGEN and others11 Abbreviations: ADNI, Alzheimer's Disease Neuroimaging Initiative (http://www.adni-info.org); CHARGE, the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (http://www.chargeconsortium.com); IMAGEN, IMAging GENetics Consortium (http://www.imagen-europe.com). , ENIGMA's genomic screens – now numbering over 30,000 MRI scans – have revealed at least 8 genetic loci that affect brain volumes. Downstream of gene findings, ENIGMA has revealed how these individual variants – and genetic variants in general – may affect both the brain and risk for a range of diseases. The ENIGMA consortium is discovering factors that consistently affect brain structure and function that will serve as future predictors linking individual brain scans and genomic data. It is generating vast pools of normative data on brain measures – from tens of thousands of people – that may help detect deviations from normal development or aging in specific groups of subjects. We discuss challenges and opportunities in applying these predictors to individual subjects and new cohorts, as well as lessons we have learned in ENIGMA's efforts so far.
- Subjects :
- 0301 basic medicine
Neuroinformatics
Candidate gene
endocrine system
Cognitive Neuroscience
Brain Structure and Function
BF
Genome-wide association study
Disease
Affect (psychology)
Article
150 000 MR Techniques in Brain Function
03 medical and health sciences
0302 clinical medicine
SDG 17 - Partnerships for the Goals
Neuroimaging
cortical surface-area
medicine
Journal Article
Humans
Multicenter Studies as Topic
alzheimers-disease
GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)
Depression (differential diagnoses)
Brain Diseases
Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7]
white-matter
Mental Disorders
[SCCO.NEUR]Cognitive science/Neuroscience
medicine.disease
heritability analysis
susceptibility loci
3. Good health
030104 developmental biology
Neurology
Evolutionary biology
Schizophrenia
22q11.2 deletion syndrome
Research Programm of Donders Centre for Neuroscience
genome-wide association
chronic-schizophrenia
genetic associations
Psychology
candidate genes
Neuroscience
030217 neurology & neurosurgery
Genome-Wide Association Study
Subjects
Details
- ISSN :
- 10538119 and 10959572
- Database :
- OpenAIRE
- Journal :
- NeuroImage, 145, 389-408, NeuroImage, 145, Pt B, pp. 389-408, Neuroimage, NeuroImage, Thompson, P M, Andreassen, O A, Arias-Vasquez, A, Bearden, C E, Boedhoe, P S, Brouwer, R M, Buckner, R L, Buitelaar, J K, Bulayeva, K B, Cannon, D M, Cohen, R A, Conrod, P, Dale, A M, Deary, I J, Dennis, E L, de Reus, M A, Desrivieres, S, Dima, D, Donohoe, G, Fisher, S E, Fouche, J-P, Francks, C, Frangou, S, Franke, B, Ganjgahi, H, Garavan, H, Glahn, D C, Grabe, H J, Guadalupe, T, Gutman, B A, Hashimoto, R, Hibar, D P, Holland, D, Hoogman, M, Pol, H E H, Hosten, N, Jahanshad, N, Kelly, S, Kochunov, P, Kremen, W S, Lee, P H, Mackey, S, Martin, N G, Mazoyer, B, McDonald, C, Medland, S E, Morey, R A, Nichols, T E, Paus, T, Pausova, Z, Schmaal, L, Schumann, G, Shen, L, Sisodiya, S M, Smit, D J A, Smoller, J W, Stein, D J, Stein, J L, Toro, R, Turner, J A, van den Heuvel, M P, van den Heuvel, O L, van Erp, T G M, van Rooij, D, Veltman, D J, Walter, H, Wang, Y, Wardlaw, J M, Whelan, C D, Wright, M J & Ye, J 2015, ' ENIGMA and the individual: Predicting factors that affect the brain in 35 countries worldwide ', NeuroImage . https://doi.org/10.1016/j.neuroimage.2015.11.057, NeuroImage, 145, 389-408. Academic Press Inc., NeuroImage, Elsevier, 2015, ⟨10.1016/j.neuroimage.2015.11.057⟩, Thompson, P M, Dennis, E L, Gutman, B A, Hibar, D P, Jahanshad, N, Kelly, S, Stein, J L, Whelan, C D, Andreassen, O A, Andreassen, O A, Arias-Vasquez, A, Bearden, C E, Bearden, C E, Bearden, C E, Boedhoe, P S, van den Heuvel, O L, Veltman, D J, Brouwer, R M, de Reus, M A, Pol, H E H, van den Heuvel, M P, Buckner, R L, Buitelaar, J K, Fisher, S E, Francks, C, Franke, B, Hoogman, M, van Rooij, D, Buitelaar, J K, Bulayeva, K B, Cannon, D M, Cannon, D M, McDonald, C, Cohen, R A, Conrod, P J, Dale, A M, Holland, D, Thompson, P M, Deary, I J, Wardlaw, J M, Desrivieres, S, Schumann, G, Dima, D, Dima, D, Frangou, S, Donohoe, G, Fisher, S E, Francks, C, Guadalupe, T, Fouche, J P, Stein, D J, Franke, B, Hoogman, M, Franke, B, Ganjgahi, H, Garavan, H, Glahn, D C, Glahn, D C, Grabe, H J, Grabe, H J, Guadalupe, T, Hashimoto, R, Hosten, N, Kochunov, P, Kremen, W S, Lee, P H, Lee, P H, Lee, P H, Mackey, S, Mazoyer, B, Martin, N G, Medland, S E, Morey, R A, Nichols, T E, Nichols, T E, Paus, T, Paus, T, Paus, T, Pausova, Z, Pausova, Z, Shen, L, Shen, L, Sisodiya, S M, Smit, D J A, Smoller, J W, Stein, D J, Stein, J L, Toro, R, Turner, J A, Boedhoe, P S, Schmaal, L, van den Heuvel, O L, Veltman, D J, Boedhoe, P S, Schmaal, L, van den Heuvel, O L, Veltman, D J, van Erp, T G M, Walter, H, Wang, Y, Wardlaw, J M, Wardlaw, J M, Wright, M J, Ye, J & Ye, J 2017, ' ENIGMA and the individual : Predicting factors that affect the brain in 35 countries worldwide ', NeuroImage, vol. 145, pp. 389-408 . https://doi.org/10.1016/j.neuroimage.2015.11.057, Thompson, P M, Dennis, E L, Gutman, B A, Hibar, D P, Jahanshad, N, Kelly, S, Stein, J L, Whelan, C D, Andreassen, O A, Arias-Vasquez, A, Bearden, C E, Boedhoe, P S, van den Heuvel, O L, Veltman, D J, Brouwer, R M, de Reus, M A, Pol, H E H, van den Heuvel, M P, Buckner, R L, Buitelaar, J K, Fisher, S E, Francks, C, Franke, B, Hoogman, M, van Rooij, D, Bulayeva, K B, Cannon, D M, McDonald, C, Cohen, R A, Conrod, P J, Dale, A M, Holland, D, Deary, I J, Wardlaw, J M, Desrivieres, S, Schumann, G, Dima, D, Dima, D, Frangou, S, Donohoe, G, Guadalupe, T, Fouche, J P, Stein, D J, Ganjgahi, H, Garavan, H, Glahn, D C, Grabe, H J, Hashimoto, R, Hosten, N, Kochunov, P, Kremen, W S, Lee, P H, Mackey, S, Mazoyer, B, Martin, N G, Medland, S E, Morey, R A, Nichols, T E, Paus, T, Pausova, Z, Shen, L, Sisodiya, S M, Smit, D J A, Smoller, J W, Toro, R, Turner, J A, Schmaal, L, van Erp, T G M, Walter, H, Wang, Y, Wright, M J & Ye, J 2017, ' ENIGMA and the individual : Predicting factors that affect the brain in 35 countries worldwide ', NeuroImage, vol. 145, pp. 389-408 . https://doi.org/10.1016/j.neuroimage.2015.11.057, NeuroImage, 145(B), 389. Academic Press Inc., NeuroImage, 2015, ⟨10.1016/j.neuroimage.2015.11.057⟩, Thompson, P M, Andreassen, O A, Arias-Vasquez, A, Bearden, C E, Boedhoe, P S, Brouwer, R M, Buckner, R L, Buitelaar, J K, Bulayeva, K B, Cannon, D M, Cohen, R A, Conrod, P J, Dale, A M, Deary, I J, Dennis, E L, de Reus, M A, Desrivieres, S, Dima, D, Donohoe, G, Fisher, S E, Fouche, J-P, Francks, C, Frangou, S, Franke, B, Ganjgahi, H, Garavan, H, Glahn, D C, Grabe, H J, Guadalupe, T, Gutman, B A, Hashimoto, R, Hibar, D P, Holland, D, Hoogman, M, Pol, H E H, Hosten, N, Jahanshad, N, Kelly, S, Kochunov, P, Kremen, W S, Lee, P H, Mackey, S, Martin, N G, Mazoyer, B, McDonald, C, Medland, S E, Morey, R A, Nichols, T E & Paus, T & Wardlaw, J M 2015, ' ENIGMA and the individual : Predicting factors that affect the brain in 35 countries worldwide ', NeuroImage . https://doi.org/10.1016/j.neuroimage.2015.11.057, Thompson, PM; Andreassen, OA; Arias-Vasquez, A; Bearden, CE; Boedhoe, PS; Brouwer, RM; et al.(2017). ENIGMA and the individual: Predicting factors that affect the brain in 35 countries worldwide. NEUROIMAGE, 145, 389-408. doi: 10.1016/j.neuroimage.2015.11.057. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/55m700sp
- Accession number :
- edsair.doi.dedup.....7524ee298ed48024f790298382b90110