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Identification of a Potential Common Ancestor for Mammalian Cross-Presenting Dendritic Cells in Teleost Respiratory Surfaces
- Source :
- Frontiers in Immunology, Vol 9 (2018), Frontiers in Immunology, Repositorio de Resultados de Investigación del INIA, INIA: Repositorio de Resultados de Investigación del INIA, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria INIA
- Publication Year :
- 2018
- Publisher :
- Frontiers Media SA, 2018.
-
Abstract
- Dendritic cells (DCs) are highly specialized antigen-presenting cells that bridge innate and adaptive immune responses in vertebrates, being key modulators in the initiation of specific responses. Although teleost fish present the main elements of a fully developed adaptive immune system, not many studies have focused on identifying specific DC subsets in teleost species. Previous work from our group identified in rainbow trout (Oncorhynchus mykiss) skin a DC subpopulation co-expressing CD8α and major histocompatibility complex II β on the cell surface. Interestingly, these CD8+ DCs expressed common unique markers of mammalian cross-presenting DCs, a DC subset with an important role in antigen presentation and activation of CD8+ T cytotoxic lymphocytes. In this study, we have identified a similar DC subset in rainbow trout gills that also transcribes molecules uniquely expressed on diverse mammalian cross-presenting DC populations such as CD8, CD103, CD141, Batf3, IFN regulatory protein 8, and toll-like receptor 3. Hence, we have undertaken a broad phenotypic and functional characterization of this new DC subset that includes the confirmation of novel capacities for DCs in teleost, such an IgM-binding capacity and responsiveness to CD40 ligand. Furthermore, our results show that in gills, this DC subset shows some different phenotypic and functional characteristics when compared with their homologs in the skin, suggesting an adaptation of the cells to different mucosal tissues or different maturation status depending on their location. Our findings contribute to increase our knowledge on fish cross-presenting DCs, an important cell population to take into account for the future design of mucosal vaccination strategies.
- Subjects :
- lcsh:Immunologic diseases. Allergy
0301 basic medicine
respiratory surfaces
animal structures
T-Lymphocytes
CD40 Ligand
Immunology
Antigen presentation
Population
Biology
Lymphocyte Activation
Major histocompatibility complex
major histocompatibility complex II
Immunophenotyping
03 medical and health sciences
Cross-Priming
Immune system
Phagocytosis
Leukocytes
Animals
Immunology and Allergy
Cytotoxic T cell
dendritic cells
14. Life underwater
education
cross-presentation
Keyword
Original Research
Cell Proliferation
Antigen Presentation
Phagocytes
education.field_of_study
gills
Fishes
Cross-presentation
CD8
Acquired immune system
rainbow trout
Cell biology
030104 developmental biology
Immunoglobulin M
biology.protein
Female
lcsh:RC581-607
Biomarkers
Subjects
Details
- ISSN :
- 16643224
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Frontiers in Immunology
- Accession number :
- edsair.doi.dedup.....752c0126770cbffaab6721b002565bf9