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Usefulness of bronchoalveolar lavage in a French pediatric cohort with hypersensitivity pneumonitis
- Source :
- Pediatric pulmonologyREFERENCES. 55(1)
- Publication Year :
- 2019
-
Abstract
- Background Hypersensitivity pneumonitis (HP) is a rare interstitial lung disease in children, and very little data are available on the frequency, diagnosis, and outcomes of HP. In a pediatric cohort with HP, the characteristics of the CD4/CD8 lymphocyte ratio are often described as nonspecific. Methods We used the National French Database (RespiRare) to collect data from the last decade on HP. The diagnosis of HP was defined by the presence of a relevant exposure, clinical symptoms, and compatible lung imaging radiology and was usually defined by positive precipitins antibodies. Results A total of 16 children with a mean age of 10 years (4-13) presented with HP. All children presented with dyspnea on exertion. Diffuse ground-glass opacity was present in all computed tomography (CT) scans. Research guided by a questionnaire and precipitins antibodies against the corresponding antigens showed that patients were positive for contact with birds with or without fungi. Bronchoalveolar lavage (BAL) was performed in 12 children. The total cell counts were elevated in BAL fluid, with a mean value of 36% lymphocytes. The CD4/CD8 lymphocyte ratio was below one for all children. Conclusion BAL in our pediatric cohort with HP had the same characteristics as that of adults with HP. An HP diagnosis must be considered when dyspnea on exertion and diffuse ground-glass opacity are observed. Carrying out BAL and serological tests can help diagnose and avoid lung biopsy.
- Subjects :
- Pulmonary and Respiratory Medicine
Male
medicine.medical_specialty
Adolescent
Lymphocyte
CD4-CD8 Ratio
Lung biopsy
Gastroenterology
Serology
03 medical and health sciences
0302 clinical medicine
030225 pediatrics
Internal medicine
medicine
Humans
Exertion
Child
Lung
medicine.diagnostic_test
business.industry
Interstitial lung disease
medicine.disease
respiratory tract diseases
Respiratory Function Tests
Bronchoalveolar lavage
medicine.anatomical_structure
Dyspnea
030228 respiratory system
Child, Preschool
Pediatrics, Perinatology and Child Health
Cohort
Female
business
Tomography, X-Ray Computed
Bronchoalveolar Lavage Fluid
Hypersensitivity pneumonitis
Alveolitis, Extrinsic Allergic
Subjects
Details
- ISSN :
- 10990496
- Volume :
- 55
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Pediatric pulmonologyREFERENCES
- Accession number :
- edsair.doi.dedup.....753dafac03ed511011f486e2521c2bed