Back to Search
Start Over
Screening of xanthine oxidase inhibitor from selected edible plants and hypouricemic effect of Rhizoma Alpiniae Officinarum extract on hyperuricemic rats
- Source :
- Journal of Functional Foods, Vol 50, Iss, Pp 26-36 (2018)
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- This study was aimed at screening a potential anti-hyperuricemia agent with dual xanthine oxidase (XOD) inhibitory effect (XOI) and antioxidant activity from edible plants with health-promoting effects using non-targeted chemometric analysis (hierarchical cluster analysis and principal component analysis), evaluating its in vivo hypouricemic effect and mechanism, and identifying the key XOD inhibitor using ultrafiltration UPLC-MS/MS. Rhizoma Alpiniae Officinarum extract (GE), which has high contents of total phenolics and flavonoids, as well as dual XOI and antioxidant activity, showed significant hypouricemic and renal protective effects on hyperuricemic rats through inhibiting XOD activity, alleviating oxidative stress, down-regulating URAT1 and GLUT9 protein expression, and reducing urea nitrogen and creatinine levels. GE could be a dual-acting agent with XOI and uricosuric effect for preventing and treating hyperuricemia. Four flavonoids and eight diarylheptanoids were identified as potential XOD inhibitors from GE. Galangin, kaempferide and 3-methoxyl-galangin contributing to 70.1% of XOI were the key XOD inhibitors.
- Subjects :
- 0301 basic medicine
Antioxidant
Uricosuric
medicine.drug_class
medicine.medical_treatment
Medicine (miscellaneous)
medicine.disease_cause
01 natural sciences
03 medical and health sciences
chemistry.chemical_compound
Diarylheptanoids
medicine
TX341-641
Hyperuricemia
Xanthine oxidase
Xanthine oxidase inhibitory effect
Xanthine oxidase inhibitor
Edible plants with health-promoting effects
Hypouricemic effect
Flavonoids
030109 nutrition & dietetics
Nutrition and Dietetics
Traditional medicine
Nutrition. Foods and food supply
010401 analytical chemistry
medicine.disease
Rhizoma Alpiniae Officinarum
0104 chemical sciences
Galangin
chemistry
Kaempferide
Oxidative stress
Food Science
Subjects
Details
- ISSN :
- 17564646
- Volume :
- 50
- Database :
- OpenAIRE
- Journal :
- Journal of Functional Foods
- Accession number :
- edsair.doi.dedup.....7549b2d364509c727ba6cf2c37e232cc